ArticleAge (Dordrecht, Netherlands)2010
The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan.
Article in Age (Dordrecht, Netherlands), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Pooled it
- Pooled it
- The influences of genetic polymorphisms in three candidate genes on the athletic performance of Korean athletes.Genes & genomics · 2025Article
- Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women.Genes · 2022Article
- The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women.Genes · 2020Article
- Beyond the Big Five: Investigating Myostatin Structure, Polymorphism and Expression inFrontiers in genetics · 2019Article
- Structure of the human myostatin precursor and determinants of growth factor latency.The EMBO journal · 2018Article
- Genetic variants associated with physical performance and anthropometry in old age: a genome-wide association study in the ilSIRENTE cohort.Scientific reports · 2017Article
- Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.Circulation research · 2016Review
- Association of the K153R polymorphism in the myostatin gene and extreme longevity.Age (Dordrecht, Netherlands) · 2013Article
- Sarcopenic obesity: how do we treat it?Current opinion in endocrinology, diabetes, and obesity · 2013Review
- Genes and the ageing muscle: a review on genetic association studies.Age (Dordrecht, Netherlands) · 2013Review
- Molecular genetic studies of gene identification for sarcopenia.Human genetics · 2012Review
- Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review.Frontiers in physiology · 2012Article
- Article
- The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men.PloS one · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the A55T, E164K, I225T, K153R and P198A variants in the myostatin (GDF8) gene, muscle strength and mass, and physical function during daily living in 41 nonagenarians [33 women, age range, 90, 97]. No participant carried a mutant allele of the aforementioned variants, except three participants (all women), who carried the R allele of the K153R polymorphism, with one of them (woman aged 96 years) being homozygous. Overall, in KR women muscle phenotype values (1RM leg press and estimated muscle mass) were low-to-normal compared to the whole group (approximately 25th-50th percentile), and their functional capacity (Barthel and Tinetti tests) was normal. In the woman bearing the RR genotype, values of muscle mass and functional capacity were below the 25th percentile. She is the first RR Caucasian whose phenotype has been characterised specifically. In summary, heterozygosity for the GDF8 K153R polymorphism does not seem to exert a negative influence on the muscle phenotypes of women who are at the end of the human lifespan, yet homozygosity might do so. More research on larger cohorts of nonagenarians is needed to corroborate the present findings.
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