ArticleTransgenic research2011
GH overexpression causes muscle hypertrophy independent from local IGF-I in a zebrafish transgenic model.
Article in Transgenic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Dietary Supplementation with Recombinant Bacillus subtilis Expressing Insulin-Like Growth Factor 1a (IGF1a) Promotes Muscle Hypertrophy in Zebrafish (Danio rerio).Probiotics and antimicrobial proteins · 2026Article
- Growth, survival, and myogenic gene expression in the post-larvae of Colossoma macropomum provisioned with Artemia nauplii.Fish physiology and biochemistry · 2024Article
- Comparison of growth performance among channel-blue hybrid catfish, ccGH transgenic channel catfish, and channel catfish in a tank culture system.Scientific reports · 2022Article
- GH Overexpression Alters Spermatic Cells MicroRNAome Profile in Transgenic Zebrafish.Frontiers in genetics · 2021Article
- Growth Hormone Overexpression Induces Hyperphagia and Intestinal Morphophysiological Adaptations to Improve Nutrient Uptake in Zebrafish.Frontiers in physiology · 2021Article
- Evaluation of qPCR reference genes in GH-overexpressing transgenic zebrafish (Danio rerio).Scientific reports · 2020Article
- Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR).Transgenic research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to analyse the morphology of white skeletal muscle in males and females from the GH-transgenic zebrafish (Danio rerio) lineage F0104, comparing the expression of genes related to the somatotrophic axis and myogenesis. Histological analysis demonstrated that transgenic fish presented enhanced muscle hypertrophy when compared to non-transgenic fish, with transgenic females being more hypertrophic than transgenic males. The expression of genes related to muscle growth revealed that transgenic hypertrophy is independent from local induction of insulin-like growth factor 1 gene (igf1). In addition, transgenic males exhibited significant induction of myogenin gene (myog) expression, indicating that myog may mediate hypertrophic growth in zebrafish males overexpressing GH. Induction of the α-actin gene (acta1) in males, independently from transgenesis, also was observed. There were no significant differences in total protein content from the muscle. Our results show that muscle hypertrophy is independent from muscle igf1, and is likely to be a direct effect of excess circulating GH and/or IGF1 in this transgenic zebrafish lineage.
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Registered trials
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