ArticleImmunogenetics2010
Diversity of MHC class I genes in Burmese-origin rhesus macaques.
Article in Immunogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuatedeLife · 2025Article
- The Impact and Effects of Host Immunogenetics on Infectious Disease Studies Using Non-Human Primates in Biomedical Research.Microorganisms · 2024Review
- Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- HIV-1 and drug abuse comorbidity: Lessons learned from the animal models of NeuroHIV.Neuroscience letters · 2021Review
- Development and evaluation of a rapid and cost-efficient NGS-based MHC class I genotyping method for macaques by using a prevalent short-read sequencer.Immunogenetics · 2021Article
- CD8 T Cells Show Protection against Highly Pathogenic Simian Immunodeficiency Virus (SIV) after Vaccination with SIV Gene-Expressing BCG Prime and Vaccinia Virus/Sendai Virus Vector Boosts.Journal of virology · 2021Article
- Therapeutic vaccine-mediated Gag-specific CD8Scientific reports · 2020Article
- MHC class I diversity of olive baboons (Papio anubis) unravelled by next-generation sequencing.Immunogenetics · 2018Article
- Diversity of ULBP5 in Old-World monkeys (Cercopithecidae) and divergence of the ULBP gene family in primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Article
- In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts.PLoS pathogens · 2017Article
- Comparative genomics of the human, macaque and mouse major histocompatibility complex.Immunology · 2017Review
- Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model.Scientific reports · 2016Article
- Biphasic CD8+ T-Cell Defense in Simian Immunodeficiency Virus Control by Acute-Phase Passive Neutralizing Antibody Immunization.Journal of virology · 2016Article
- MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection.Frontiers in immunology · 2015Review
- Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers.PLoS pathogens · 2015Article
- Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques.Immunogenetics · 2014Article
- Control of simian immunodeficiency virus replication by vaccine-induced Gag- and Vif-specific CD8+ T cells.Journal of virology · 2014Article
- Identification of MHC class I sequences in four species of Macaca of China.Immunogenetics · 2013Article
- Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.Immunogenetics · 2013Article
- Major histocompatibility complex class I haplotype diversity in Chinese rhesus macaques.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhesus macaques (Macaca mulatta) are widely used in developing a strategy for vaccination against human immunodeficiency virus by using simian immunodeficiency virus infection as a model system. Because the genome diversity of major histocompatibility complex (MHC) is well known to control the immune responsiveness to foreign antigens, MHC loci in Indian- and Chinese-origin macaques used in the experiments have been characterized, and it was revealed that the diversity of MHC in macaques was larger than the human MHC. To further characterize the diversity of Mamu-A and Mamu-B loci, we investigated a total of 73 different sequences of Mamu-A, 83 sequences of Mamu-B, and 15 sequences of Mamu-I cDNAs isolated from Burmese-origin macaques. It was found that there were one to five expressing genes in each locus. Among the Mamu-A, Mamu-B, and Mamu-I sequences, 44 (60.2%), 45 (54.2%), and 8 (53.3%), respectively, were novel, and most of the other known alleles were identical to those reported from Chinese- or Indian-origin macaques, demonstrating a genetic mixture between the geographically distinct populations of present day China and India. In addition, it was found that a Mamu haplotype contained at least two highly transcribed Mamu-A genes, because multiple Mamu-A1 cDNAs were obtained from one haplotype. These findings further revealed the diversity and complexity of MHC locus in the rhesus macaques.
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