ArticleFrontiers in neuroanatomy2010
Postnatal development of the endbulb of held in congenitally deaf cats.
Article in Frontiers in neuroanatomy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Mechanisms of age-related hearing loss at the auditory nerve central synapses and postsynaptic neurons in the cochlear nucleus.Hearing research · 2024Review
- Purinergic Modulation of Activity in the Developing Auditory Pathway.Neuroscience bulletin · 2020Review
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Transmission of auditory sensory information decreases in rate and temporal precision at the endbulb of Held synapse during age-related hearing loss.Journal of neurophysiology · 2016Article
- The Diversity of Spine Synapses in Animals.Neuromolecular medicine · 2016Review
- Monaural Congenital Deafness Affects Aural Dominance and Degrades Binaural Processing.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held.The Journal of physiology · 2015Article
- Article
- Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats.G3 (Bethesda, Md.) · 2014Article
- Morphological and physiological development of auditory synapses.Hearing research · 2014Review
- Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.The EMBO journal · 2014Article
- Functional and structural changes throughout the auditory system following congenital and early-onset deafness: implications for hearing restoration.Frontiers in systems neuroscience · 2013Review
- Synaptic plasticity in the medial superior olive of hearing, deaf, and cochlear-implanted cats.The Journal of comparative neurology · 2012Article
- Auditory neuroanatomy: a sound foundation for sound processing.Frontiers in neuroanatomy · 2012Article
- Development of brainstem-evoked responses in congenital auditory deprivation.Neural plasticity · 2012Article
- Synaptic morphology and the influence of auditory experience.Hearing research · 2011Review
- The effect of cochlear-implant-mediated electrical stimulation on spiral ganglion cells in congenitally deaf white cats.Journal of the Association for Research in Otolaryngology : JARO · 2010Article
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4 authors.
Funding
Abstract
The endbulbs of Held are formed by the ascending branches of myelinated auditory nerve fibers and represent one of the largest synaptic endings in the brain. Normally, these endings are highly branched and each can form up to 1000 dome-shaped synapses. The deaf white cat is a model of congenital deafness involving a type of cochleosaccular degeneration that mimics the Scheibe deformity in humans. Endbulbs of mature deaf white cats exhibit reduced branching, hypertrophy of postsynaptic densities (PSDs), and changes in synaptic vesicle density. Because cats are essentially deaf at birth, we sought to determine if the progression of brain abnormalities was linked in time to the failure of normal hearing development. The rationale was that the lack of sound-evoked activity would trigger pathologic change in deaf kittens. The cochleae of deaf cats did not exhibit abnormal morphology at birth. After the first postnatal week, however, the presence of a collapsed scala media signaled the difference between deaf and hearing cats. By working backwards in age, endbulbs of deaf cats expressed flattened and elongated PSDs and increased synaptic vesicle density as compared to normal endbulbs. These differences are present at birth in some white kittens, presaging deafness despite their normal cochlear histology. We speculate that hearing pathology is signaled by a perinatal loss of spontaneous bursting activity in auditory nerve fibers or perhaps by some factor released by hair cell synapses before obliteration of the organ of Corti.
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