ReviewCurrent opinion in oncology2010
Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa.
Review in Current opinion in oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis.British journal of cancer · 2013Pooled it
- Factors influencing delayed presentation of periorbital carcinoma requiring orbital exenteration.Journal of the colleges of medicine of South Africa · 2025Article
- Review
- [OCULO-ORBITAL TUMOURS AT THE NATIONAL UNIVERSITY HOSPITAL CENTRE OF BANGUI (CNHUB), CENTRAL AFRICAN REPUBLIC, IN 2022].Medecine tropicale et sante internationale · 2023Observational
- Epstein-Barr Virus, But Not Human Papillomavirus, Is Associated With Preinvasive and Invasive Ocular Surface Squamous Neoplasias in Zambian Patients.Frontiers in oncology · 2022Article
- Histopathological profile of orbito-ocular cancers at a tertiary hospital in Northern Malawi: a retrospective cross-sectional study.BMJ open ophthalmology · 2022Article
- Record linkage to correct under-ascertainment of cancers in HIV cohorts: The Sinikithemba HIV clinic linkage project.International journal of cancer · 2016Article
- Autoimmunity and dysmetabolism of human acquired immunodeficiency syndrome.Immunologic research · 2016Review
- Cancer in the HIV-Infected Host: Epidemiology and Pathogenesis in the Antiretroviral Era.Current HIV/AIDS reports · 2015Review
- Comparative Analysis of Clinical Factors Associated with Ocular Surface Squamous Neoplasia in HIV Infected and Non HIV Patients.Journal of clinical and diagnostic research : JCDR · 2015Article
- HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa: a cross-sectional study.BMC cancer · 2015Article
- Morphological Spectrum of Orbitoocular Diseases in a Tertiary Health Centre in Keffi, North Central Nigeria.Advances in medicine · 2015Article
- Challenges in the detection, prevention, and treatment of HIV-associated malignancies in low- and middle-income countries in Africa.Journal of acquired immune deficiency syndromes (1999) · 2014Review
- Surgical versus medical treatment of ocular surface squamous neoplasia: a comparison of recurrences and complications.Ophthalmology · 2014Article
- Correlation of EGFR, pEGFR and p16INK4 expressions and high risk HPV infection in HIV/AIDS-related squamous cell carcinoma of conjunctiva.Infectious agents and cancer · 2014Article
- Diagnosing ocular surface squamous neoplasia in East Africa: case-control study of clinical and in vivo confocal microscopy assessment.Ophthalmology · 2014Article
- Ocular surface squamous neoplasia in HIV-positive and HIV-negative patients and response to 5-fluorouracil in Angola.Clinical ophthalmology (Auckland, N.Z.) · 2014Article
- Developing clinical strength-of-evidence approach to define HIV-associated malignancies for cancer registration in Kenya.PloS one · 2014Article
- Predictors of ocular surface squamous neoplasia recurrence after excisional surgery.Ophthalmology · 2012Article
- Prevalence and Severity of Ocular Surface Neoplasia in African Nations and Need for Early Interventions.Journal of ophthalmic & vision researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
purpose of reviewOcular surface squamous neoplasia (OSSN) in sub-Saharan countries is an aggressive tumor that affects younger patients and appears to be increasing in incidence. There are data to suggest the association of this disease with solar radiation exposure, HIV, and human papilloma virus (HPV). This trend possibly reflects the association of the high incidence of HIV, concomitant high incidence of exposure to HPV, and the solar radiation exposure that people in this region of the world receive. We undertook a PubMed search with the terms 'ocular surface squamous neoplasia', 'conjunctival carcinoma', 'HIV' and 'HPV', and 'sub-Saharan/Africa' to ascertain the scope of the problem and to review the available data, with an emphasis on publications of 2009 and the first quarter of 2010. RECENT
findingsThere is increasing evidence of a significant association between HIV seropositivity and OSSN. The role of HPV as contributing to the cause of OSSN is being investigated. SUMMARY: Patients with conjunctival cancer in sub-Saharan Africa are typically younger and more than 50% have underlying HIV infection. Initial presentation can be asymptomatic; however, many of these patients have advanced disease before they seek medical help and OSSN appears to have a more aggressive clinical course in sub-Saharan Africa. Treatment in Africa is primarily surgical. Chemotherapy and antiviral agents have been used. A diagnosis of OSSN in younger patients in sub-Saharan Africa should prompt HIV serotesting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.