ArticleDevelopmental neuroscience2010
Brain-derived neurotrophic factor attracts geniculate ganglion neurites during embryonic targeting.
Article in Developmental neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Reduced mechanical shear is associated with early cortical differentiation and GDNF-GFRA1/RET signalling in human brain organoids.Stem cells translational medicine · 2026Article
- Neurological Effects ofNutrients · 2026Article
- BDNF Overexpression Enhances Neuronal Activity and Axonal Growth in Human iPSC-Derived Neural Cultures.International journal of molecular sciences · 2025Article
- Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Review
- TrkB expression and dependence divides gustatory neurons into three subpopulations.Neural development · 2019Article
- Maintenance of Mouse Gustatory Terminal Field Organization Is Dependent on BDNF at Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway.Neurobiology of disease · 2018Article
- BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section.Experimental neurology · 2017Article
- Decoding the ubiquitous role of microRNAs in neurogenesis.Molecular neurobiology · 2017Review
- Ephrin-B/EphB Signaling Is Required for Normal Innervation of Lingual Gustatory Papillae.Developmental neuroscience · 2016Article
- Postnatal reduction of BDNF regulates the developmental remodeling of taste bud innervation.Developmental biology · 2015Article
- Role of neurotrophin in the taste system following gustatory nerve injury.Metabolic brain disease · 2015Review
- The neurotrophin receptor p75 regulates gustatory axon branching and promotes innervation of the tongue during development.Neural development · 2014Article
- BDNF and NT4 play interchangeable roles in gustatory development.Developmental biology · 2014Article
- The role of microRNAs in regulating neuronal connectivity.Frontiers in cellular neuroscience · 2014Review
- Cell signaling experiments driven by optical manipulation.International journal of molecular sciences · 2013Review
- Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation.PloS one · 2013Article
- Neurotrophin-4 regulates the survival of gustatory neurons earlier in development using a different mechanism than brain-derived neurotrophic factor.Developmental biology · 2012Article
- microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons.Nature neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Geniculate axons are initially guided to discrete epithelial placodes in the lingual and palatal epithelium that subsequently differentiate into taste buds. In vivo approaches show that brain-derived neurotrophic factor (BDNF) mRNA is concentrated in these placodes, that BDNF is necessary for targeting taste afferents to these placodes, and that BDNF misexpression disrupts guidance. We used an in vitro approach to determine whether BDNF may act directly on geniculate axons as a trophic factor and as an attractant, and whether there is a critical period for responsiveness to BDNF. We show that BDNF promotes neurite outgrowth from geniculate ganglion explants dissected from embryonic day (E) 15, E18, infant, and adult rats cultured in collagen gels, and that there is a concentration optimum for neurite extension. Gradients of BDNF derived from slow-release beads caused the greatest bias in neurite outgrowth at E15, when axons approach the immature gustatory papillae. Further, neurites advanced faster toward the BDNF bead than away from it, even if the average amount of neurotrophic factor encountered was the same. We also found that neurites that contact BDNF beads did not advance beyond them. At E18, when axons would be penetrating pregustatory epithelium in vivo, BDNF continued to exert a tropic effect on geniculate neurites. However, at postnatal and adult stages, the influence of BDNF was predominantly trophic. Our data support a role for BDNF acting as an attractant for geniculate axons during a critical period that encompasses initial targeting but not at later stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.