ReviewJournal of dental research2010
"Gum bug, leave my heart alone!"--epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis.
Review in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
202 citing papers in PubMed, 10 syntheses or guidelines pooled it, 444 citations in OpenAlex.
- Thermosensitive Hydrogels for Periodontal Regeneration: A Systematic Review of the Evidence.Clinical and experimental dental research · 2024Pooled it
- Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Efficacy of non-surgical periodontal treatment on patients with coronary artery disease: a meta-analysis of randomized controlled trials.Medicina oral, patologia oral y cirugia bucal · 2022Pooled it
- Is periodontal disease a risk indicator for urogenital cancer? A systematic review and meta-analysis of cohort studies.Frontiers in oncology · 2022Pooled it
- Effects of non-surgical periodontal therapy on periodontal clinical data in periodontitis patients with rheumatoid arthritis: a meta-analysis.BMC oral health · 2021Pooled it
- Pooled it
- Teeth loss, teeth brushing and esophageal carcinoma: a systematic review and meta-analysis.Scientific reports · 2015Pooled it
- The potential association between gingival crevicular fluid inflammatory mediators and adverse pregnancy outcomes: a systematic review.Clinical oral investigations · 2013Pooled it
- Pooled it
- The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis.Clinical oral investigations · 2012Pooled it
- Nonsurgical periodontal therapy with/without 980 nm diode laser in patients after myocardial infarction: a randomized clinical trial.Lasers in medical science · 2021Trial
- Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients.Scientific reports · 2021Trial
- Trial
- Association of tooth loss and oral hygiene with risk of gastric adenocarcinoma.Cancer prevention research (Philadelphia, Pa.) · 2013Trial
- Integrating machine learning and multi-omics analysis to identify and validate key genes associated with periodontitis.Acta odontologica Scandinavica · 2026Article
- Myeloid-Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Involvement of Megasphaera in the oral microbiome and dyslipidemia onset: evidence from a community-based study in Japan.Folia microbiologica · 2026Article
- Characterize Oral-to-Blood Microbial DNA Translocation in Individuals with Cocaine Use Disorder.bioRxiv : the preprint server for biology · 2026Article
- Endodontic Inflammatory Disease: Systemic Consequences.Advances in experimental medicine and biology · 2026Review
- Article
142 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Evidence from epidemiologic studies suggests that periodontal infections are independently associated with subclinical and clinical atherosclerotic vascular disease. Although the strength of the reported associations is modest, the consistency of the data across diverse populations and a variety of exposure and outcome variables suggests that the findings are not spurious or attributable only to the effects of confounders. Analysis of limited data from interventional studies suggests that periodontal treatment generally results in favorable effects on subclinical markers of atherosclerosis, although such analysis also indicates considerable heterogeneity in responses. Experimental mechanistic in vitro and in vivo studies have established the plausibility of a link between periodontal infections and atherogenesis, and have identified biological pathways by which these effects may be mediated. However, the utilized models are mostly mono-infections of host cells by a limited number of 'model' periodontal pathogens, and therefore may not adequately portray human periodontitis as a polymicrobial, biofilm-mediated disease. Future research must identify in vivo pathways in humans that may (i) lead to periodontitis-induced atherogenesis, or (ii) result in treatment-induced reduction of atherosclerosis risk. Data from these studies will be essential for determining whether periodontal interventions have a role in the primary or secondary prevention of atherosclerosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.