ArticleJournal of immunology (Baltimore, Md. : 1950)2010
B7-H1 (programmed cell death ligand 1) is required for the development of multifunctional Th1 cells and immunity to primary, but not secondary, Salmonella infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Noncanonical PD-1/PD-L1 Axis in Relation to the Efficacy of Anti-PD Therapy.Frontiers in immunology · 2022Review
- Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions.Journal of virology · 2019Article
- PD-L1 serves as a double agent in separating GVL from GVHD.The Journal of clinical investigation · 2017Article
- Characterization of regulatory dendritic cells differentiated from the bone marrow of UV-irradiated mice.Immunology · 2013Article
- The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses.Trends in immunology · 2013Review
- A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection.PloS one · 2013Article
- Innate IFN-γ is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Active evasion of CTL mediated killing and low quality responding CD8+ T cells contribute to persistence of brucellosis.PloS one · 2012Article
- B7-h1 expressed by activated CD8 T cells is essential for their survival.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda.Mucosal immunology · 2011Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Robust Ab and CD4 T cell responses are required for the resolution of Salmonella infection in susceptible mice. In this study, we examined the role of B7-H1 (programmed cell death ligand 1) in resistance to primary Salmonella infection. Infected B7-H1-deficient mice had significantly higher bacterial burdens at day 21 and day 35 postinfection compared with wild-type mice, demonstrating that B7-H1 plays an important role in immunity to Salmonella. B7-H1-deficient and wild-type mice both generated Salmonella-specific IgM and IgG2c Ab responses to infection, and clonal expansion of endogenous and adoptively transferred Salmonella-specific CD4 T cells was similar in both groups. However, although Salmonella-specific IFN-gamma-producing Th1 CD4 T cells were generated in Salmonella-infected B7-H1-deficient mice, these cells did not expand to the level observed in wild-type mice. Furthermore, fewer multifunctional Th1 cells that simultaneously secreted IFN-gamma, TNF-alpha, and IL-2 were detected in Salmonella-infected B7-H1-deficient mice. Together, these data demonstrate that B7-H1 is required for the generation of multifunctional Th1 responses and optimal protective immunity to primary Salmonella infection.
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