ArticleThe Plant cell2010
A nitrogen response pathway regulates virulence functions in Fusarium oxysporum via the protein kinase TOR and the bZIP protein MeaB.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 256 citations in OpenAlex.
- Cordycepin suppresses growth and virulence ofVirulence · 2026Article
- Carbon and nitrogen availability affects biofilm growth and morphology of the extremotolerant fungusApplied and environmental microbiology · 2026Article
- Metabolic Engineering for Gibberellic Acid Production inMolecules (Basel, Switzerland) · 2026Review
- BsSYT1 is required for growth, conidiogenesis, stress response and virulence of Bipolaris sorokiniana.World journal of microbiology & biotechnology · 2026Article
- The Nitrogen Regulatory Gene ntrC Modulates Virulence and Nitrogen Metabolism in Burkholderia glumae.The plant pathology journal · 2026Article
- BdAreA regulates nitrogen metabolism, stress response, and virulence in Botryosphaeria dothidea.Crop health · 2026Article
- Facultative heterochromatin mediated by core and accessory chromosome-encoded H3K27-specific methyltransferases controls virulence in a fungal phytopathogen.Nucleic acids research · 2026Article
- Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025Review
- Host-specific adaptation inmBio · 2025Article
- Cell wall remodeling in a fungal pathogen is required for hyphal growth into microspaces.mBio · 2025Article
- Transposons and accessory genes drive adaptation in a clonally evolving fungal pathogen.Nature communications · 2025Article
- Virulence ofbioRxiv : the preprint server for biology · 2025Article
- The TOR signalling pathway in fungal phytopathogens: A target for plant disease control.Molecular plant pathology · 2024Review
- Copper acquisition is essential for plant colonization and virulence in a root-infecting vascular wilt fungus.PLoS pathogens · 2024Article
- The Ubiquitous Wilt-Inducing PathogenPathogens (Basel, Switzerland) · 2024Review
- Article
- Zinc finger transcription factor ZFP1 is associated with growth, conidiation, osmoregulation, and virulence in the Polygonatum kingianum pathogen Fusarium oxysporum.Scientific reports · 2024Article
- Fusarium graminearum rapid alkalinization factor peptide negatively regulates plant immunity and cell growth via the FERONIA receptor kinase.Plant biotechnology journal · 2024Article
- Regulation of nitrogen utilization and mycotoxin biosynthesis by the GATA transcription factor AaAreA in Alternaria alternata.World journal of microbiology & biotechnology · 2024Article
- The basic leucine zipper transcription factor MeaB is critical for biofilm formation, cell wall integrity, and virulence inmSphere · 2024Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During infection, fungal pathogens activate virulence mechanisms, such as host adhesion, penetration and invasive growth. In the vascular wilt fungus Fusarium oxysporum, the mitogen-activated protein kinase Fmk1 is required for plant infection and controls processes such as cellophane penetration, vegetative hyphal fusion, or root adhesion. Here, we show that these virulence-related functions are repressed by the preferred nitrogen source ammonium and restored by treatment with l-methionine sulfoximine or rapamycin, two specific inhibitors of Gln synthetase and the protein kinase TOR, respectively. Deletion of the bZIP protein MeaB also resulted in nitrogen source-independent activation of virulence mechanisms. Activation of these functions did not require the global nitrogen regulator AreA, suggesting that MeaB-mediated repression of virulence functions does not act through inhibition of AreA. Tomato plants (Solanum lycopersicum) supplied with ammonium rather than nitrate showed a significant reduction in vascular wilt symptoms when infected with the wild type but not with the DeltameaB strain. Nitrogen source also affected invasive growth in the rice blast fungus Magnaporthe oryzae and the wheat head blight pathogen Fusarium graminearum. We propose that a conserved nitrogen-responsive pathway might operate via TOR and MeaB to control virulence in plant pathogenic fungi.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.