ArticleThe Plant cell2010
DNA replication factor C1 mediates genomic stability and transcriptional gene silencing in Arabidopsis.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 62 citations in OpenAlex.
- Interspecies rice versus Arabidopsis thaliana protein-protein interactome profiling by touch-down overlapping PCR coupled with HiFi long-read sequencing.Journal of integrative plant biology · 2026Article
- Expanding the genetic and phenotypic landscape of replication factor C complex-related disorders: RFC4 deficiency is linked to a multisystemic disorder.American journal of human genetics · 2024Article
- Comprehensive Analysis of a Japanese Pedigree with Biallelic ACAGG Expansions in RFC1 Manifesting Motor Neuronopathy with Painful Muscle Cramps.Cerebellum (London, England) · 2024Article
- Article
- The role of ATXR6 expression in modulating genome stability and transposable element repression inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Polymorphisms inFrontiers in veterinary science · 2022Article
- Combining Proteomics and Metabolomics to Analyze the Effects of Spaceflight on Rice Progeny.Frontiers in plant science · 2022Article
- Telomerase Interaction Partners-Insight from Plants.International journal of molecular sciences · 2021Article
- Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cycle to RNA polymerase I transcription.Molecular biology of the cell · 2021Article
- DNA polymerase epsilon is required for heterochromatin maintenance in Arabidopsis.Genome biology · 2020Article
- Plant DNA Polymerases.International journal of molecular sciences · 2019Review
- Active DNA Demethylation in Plants.International journal of molecular sciences · 2019Review
- Interactional similarities and differences in the protein complex of PCNA and DNA replication factor C between rice and Arabidopsis.BMC plant biology · 2019Article
- Peroxisomal β-oxidation regulates histone acetylation and DNA methylation inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE Play Overlapping Roles in the Maintenance of Epigenome and Genome Stability.The Plant cell · 2018Article
- Subunit Interaction Differences Between the Replication Factor C Complexes inFrontiers in plant science · 2018Article
- The plant cell cycle: Pre-Replication complex formation and controls.Genetics and molecular biology · 2017Article
- The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.The EMBO journal · 2016Article
- Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis.The Plant journal : for cell and molecular biology · 2016Article
- The Second Subunit of DNA Polymerase Delta Is Required for Genomic Stability and Epigenetic Regulation.Plant physiology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Genetic screening identified a suppressor of ros1-1, a mutant of REPRESSOR OF SILENCING1 (ROS1; encoding a DNA demethylation protein). The suppressor is a mutation in the gene encoding the largest subunit of replication factor C (RFC1). This mutation of RFC1 reactivates the unlinked 35S-NPTII transgene, which is silenced in ros1 and also increases expression of the pericentromeric Athila retrotransposons named transcriptional silent information in a DNA methylation-independent manner. rfc1 is more sensitive than the wild type to the DNA-damaging agent methylmethane sulphonate and to the DNA inter- and intra- cross-linking agent cisplatin. The rfc1 mutant constitutively expresses the G2/M-specific cyclin CycB1;1 and other DNA repair-related genes. Treatment with DNA-damaging agents mimics the rfc1 mutation in releasing the silenced 35S-NPTII, suggesting that spontaneously induced genomic instability caused by the rfc1 mutation might partially contribute to the released transcriptional gene silencing (TGS). The frequency of somatic homologous recombination is significantly increased in the rfc1 mutant. Interestingly, ros1 mutants show increased telomere length, but rfc1 mutants show decreased telomere length and reduced expression of telomerase. Our results suggest that RFC1 helps mediate genomic stability and TGS in Arabidopsis thaliana.
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Registered trials
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