ArticleNeuropharmacology2010
Withdrawal from chronic amphetamine produces persistent anxiety-like behavior but temporally-limited reductions in monoamines and neurogenesis in the adult rat dentate gyrus.
Article in Neuropharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review.Frontiers in pharmacology · 2024Pooled it
- The effects of ketamine on methamphetamine withdrawal-induced anxiety and drug-seeking behaviors in the rat.Drug and alcohol dependence · 2025Article
- Plasticity of ventral tegmental area disturbance during abstinence after repeated amphetamine exposure: restoration by selective activation of group II metabotropic glutamate receptors.Frontiers in pharmacology · 2025Article
- Article
- Amphetamine-induced prolonged disturbances in tissue levels of dopamine and serotonin in the rat brain.Pharmacological reports : PR · 2023Article
- Amphetamine exposure alters behaviors, and neuronal and neurochemical activation in the brain of female prairie voles.Neuroscience · 2022Article
- Prolonged Peripheral Immunosuppressive Responses as Consequences of Random Amphetamine Treatment, Amphetamine Withdrawal and Subsequent Amphetamine Challenges in Rats.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Glycogen Synthase Kinase 3β in the Ventral Hippocampus is Important for Cocaine Reward and Object Location Memory.Neuroscience · 2020Article
- The future of rodent models in depression research.Nature reviews. Neuroscience · 2019Review
- Amphetamine Self-Administration and Its Extinction Alter the 5-HTNeurotoxicity research · 2019Article
- Bone Marrow Derived Mesenchymal Stem Cells in Addiction Related Hippocampal Damages.International journal of molecular and cellular medicine · 2018Review
- Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice.The international journal of neuropsychopharmacology · 2017Article
- Anxiety level and correlates in methamphetamine-dependent patients during acute withdrawal.Medicine · 2017Article
- Iron Oxide Nanoparticle Delivery of Peptides to the Brain: Reversal of Anxiety during Drug Withdrawal.Frontiers in neuroscience · 2017Article
- Timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine DNeuroscience · 2016Article
- Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling.Journal of biomedical science · 2016Article
- Amphetamine withdrawal differentially affects hippocampal and peripheral corticosterone levels in response to stress.Brain research · 2016Article
- Effects of addictive drugs on adult neural stem/progenitor cells.Cellular and molecular life sciences : CMLS · 2016Review
- Effects of chronic administration of fenproporex on cognitive and non-cognitive behaviors.Metabolic brain disease · 2015Article
- Activity-regulated gene expression in immature neurons in the dentate gyrus following re-exposure to a cocaine-paired environment.Hippocampus · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Acute amphetamine administration activates monoaminergic pathways and increases systemic corticosterone, both of which influence anxiety states and adult dentate gyrus neurogenesis. Chronic amphetamine increases anxiety states in rats when measured at 24 h and at 2 weeks of withdrawal. However, the effects of chronic amphetamine exposure and withdrawal on long term anxiety-like behavior and adult neurogenesis in the dentate gyrus are unknown. Adult male rats were administered amphetamine (2.5 mg/kg, ip.) daily for two weeks. Anxiety-like behaviors were increased markedly in amphetamine-treated rats following four weeks of withdrawal from amphetamine. Plasma corticosterone level was unaltered by amphetamine treatment or withdrawal. However, norepinephrine and serotonin concentrations were selectively reduced in the dentate gyrus 20 h following amphetamine treatment. This effect did not persist through the four week withdrawal period. In separate experiments, rats received bromodeoxyuridine to label cells in S-phase, prior to or immediately following amphetamine treatment. Newly generated cells were quantified to measure extent of progenitor cell proliferation and neurogenesis following treatment or withdrawal. Progenitor cell proliferation and neurogenesis were not significantly affected by amphetamine exposure when measured 20 h following the last amphetamine treatment. However, neurogenesis in the dentate gyrus was reduced after four weeks of withdrawal when compared to saline-pretreated rats. Overall, our findings indicate that withdrawal from chronic amphetamine leads to persistent anxiety-like behavior which may be maintained by reduced neurogenesis in the dentate gyrus at this protracted withdrawal time point. However, neurogenesis is unaffected at earlier withdrawal time points where anxiety states emerge, suggesting different mechanisms may underlie the emergence of anxiety states during amphetamine withdrawal.
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