ArticleHeart rhythm2010
Light-to-moderate alcohol consumption and risk of sudden cardiac death in women.
Article in Heart rhythm, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A burden of proof study on alcohol consumption and ischemic heart disease.Nature communications · 2024Pooled it
- Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.BMJ (Clinical research ed.) · 2017Trial
- Long-term alcohol and caffeine intake and risk of sudden cardiac death in women.The American journal of clinical nutrition · 2013Trial
- Cardiac Responses to Alcohol: A Review of Mechanisms and Clinical Implications.Reviews in cardiovascular medicine · 2026Review
- Health effects associated with alcohol consumption: a Burden of Proof study.Nature health · 2026Article
- Management of patients with an electrical storm or clustered ventricular arrhythmias: a clinical consensus statement of the European Heart Rhythm Association of the ESC-endorsed by the Asia-Pacific Heart Rhythm Society, Heart Rhythm Society, and Latin-American Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice.Communications biology · 2023Article
- Alcohol and Cardiac Arrythmias: A Review of the Current Data.Reviews in cardiovascular medicine · 2023Review
- Alcohol intake and bradyarrhythmia risk: a cohort study of 407 948 individuals.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Article
- Alcohol and Cardiovascular Diseases-Do the Consumption Pattern and Dose Make the Difference?Journal of cardiovascular development and disease · 2022Review
- Analyzing Untreated Alcohol Use Disorder and Factors Related to Help-Seeking Status.Psychiatry investigation · 2021Article
- Alcohol consumption and risk of cardiovascular outcomes and bleeding in patients with established atrial fibrillation.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021Observational
- Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models.Frontiers in cardiovascular medicine · 2019Review
- An Autopsy Case of Sudden Unexpected Death of a Young Adult in a Hot Bath: Molecular Analysis Using Next-Generation DNA Sequencing.Clinical medicine insights. Case reports · 2017Article
- Key Findings on Alcohol Consumption and a Variety of Health Outcomes From the Nurses' Health Study.American journal of public health · 2016Review
- Acute effects of ethanol on action potential and intracellular Ca(2+) transient in cardiac ventricular cells: a simulation study.Medical & biological engineering & computing · 2016Article
- The spectrum of epidemiology underlying sudden cardiac death.Circulation research · 2015Review
- Alcohol consumption and risk of heart failure: the Atherosclerosis Risk in Communities Study.European heart journal · 2015Observational
- Incidence and risk factors of ventricular fibrillation before primary angioplasty in patients with first ST-elevation myocardial infarction: a nationwide study in Denmark.Journal of the American Heart Association · 2015Article
- Focus on: women and the costs of alcohol use.Alcohol research : current reviews · 2013Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundModerate alcohol intake is associated with lower risk of coronary heart disease (CHD), but the association with sudden cardiac death (SCD) is less clear. In men, heavy alcohol consumption may increase risk of SCD, whereas light-to-moderate alcohol intake may lower risk. There are no parallel data among women.
objectiveThe purpose of this study was to assess the association between alcohol intake and risk of SCD among women and to investigate how this risk compared to other forms of CHD.
methodsWe conducted a prospective cohort study among 85,067 women from the Nurses' Health Study who were free of chronic disease at baseline. Alcohol intake was assessed every 4 years through questionnaires. Primary endpoints included SCD, fatal CHD, and nonfatal myocardial infarction.
resultsWe found a U-shaped association between alcohol intake and risk of SCD, with the lowest risk among women who drank 5.0-14.9 g/day of alcohol (P for quadratic trend = 0.02). Compared to abstainers, the multivariate relative risk (95% confidence interval) for SCD was 0.79 (0.55-1.14) for former drinkers, 0.77 (0.57-1.06) for 0.1-4.9 g/day, 0.64 (0.43-0.95) for 5.0-14.9 g/day, 0.68 (0.38-1.23) for 15.0-29.9 g/day, and 1.15 (0.70-1.87) for ≥30.0 g/day. In contrast, the relationship of alcohol intake and nonfatal and fatal CHD was more linear (P for linear trend <.001).
conclusionIn this cohort of women, the relationship between light-to-moderate alcohol intake and SCD is U-shaped, with a nadir at 5.0-14.9 g/day. Low levels of alcohol intake do not raise the risk of SCD and may lower risk in women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.