ReviewCurrent opinion in genetics & development2010
Pioneer factors in embryonic stem cells and differentiation.
Review in Current opinion in genetics & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Detection of new pioneer transcription factors as cell-type-specific nucleosome binders.eLife · 2024Article
- Structural Plasticity of Pioneer Factor Sox2 and DNA Bendability Modulate Nucleosome Engagement and Sox2-Oct4 Synergism.Journal of molecular biology · 2023Article
- PBX1, EMCN and ERG are associated with the sub-clusters and the prognosis of VHL mutant clear cell renal cell carcinoma.Scientific reports · 2022Article
- Different SP1 binding dynamics at individual genomic loci in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Encounters across networks: Windows into principles of genomic regulation.Marine genomics · 2019Article
- BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV.Life science alliance · 2019Article
- Cryo-EM structure of the nucleosome containing theOpen biology · 2018Article
- YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State.Stem cells (Dayton, Ohio) · 2017Article
- Comparison of Genome-Wide and Gene-Specific DNA Methylation Profiling in First-Trimester Chorionic Villi From Pregnancies Conceived With Infertility Treatments.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- mTFkb: a knowledgebase for fundamental annotation of mouse transcription factors.Scientific reports · 2017Article
- Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation.Molecular cell · 2017Article
- PBX1 as Pioneer Factor: A Case Still Open.Frontiers in cell and developmental biology · 2017Review
- Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration.Current neurology and neuroscience reports · 2016Review
- Early enhancer establishment and regulatory locus complexity shape transcriptional programs in hematopoietic differentiation.Nature genetics · 2015Article
- Cell replacement therapy for central nervous system diseases.Neural regeneration research · 2015Review
- Investigating the transcriptional control of cardiovascular development.Circulation research · 2015Review
- Differential Nucleosome Occupancies across Oct4-Sox2 Binding Sites in Murine Embryonic Stem Cells.PloS one · 2015Article
- FOXA1 positively regulates gene expression by changing gene methylation status in human breast cancer MCF-7 cells.International journal of clinical and experimental pathology · 2015Article
- Gene activation and cell fate control in plants: a chromatin perspective.Cellular and molecular life sciences : CMLS · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Most studies of tissue-specific and developmental stage-specific transcription have focused on the DNA motifs, transcription factors, or chromatin events required for the active transcription of a gene in cells in which the gene is expressed, or for its active or heritable silencing in nonexpressing cells. However, accumulating evidence suggests that, in multicellular eukaryotes, enhancers or promoters for tissue-specific genes interact with pioneer transcription factors in embryonic stem cells and at other early stages of development, long before the genes are transcribed. These early interactions, which can lead to the presence of unmethylated CpG dinucleotides, histone modification signatures, and/or chromatin remodeling, may carry out different functions at different classes of genes.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.