Evidence map›Paper›PMID 20638248›Full record

ArticleSchizophrenia research2010

Reduced gray matter in the anterior cingulate gyrus in familial schizophrenia: a preliminary report.

Gregory Costain, Andrew Ho, Adrian P Crawley, David J Mikulis, Linda M Brzustowicz, Eva W C Chow, Anne S Bassett

Open access · greenAbstract read
In one paragraph

Article in Schizophrenia research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Gregory CostainClinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Andrew Ho
Adrian P Crawley
David J Mikulis
Linda M Brzustowicz
Eva W C Chow
Anne S Bassett
Centre for Addiction and Mental Health · CAToronto Western Hospital · CARutgers, The State University of New Jersey · US

Funding

CIHR 53216CIHR MOP-53216NIMH NIH HHS R01 MH64220
6 · The paper itself

Abstract

Few brain imaging studies of schizophrenia involve samples with enhanced genetic homogeneity. We compared MRI volumetric data between individuals with 1q21-q23 linked familial schizophrenia associated with NOS1AP and their first and second degree unaffected relatives. We found significant gray matter reductions in the anterior cingulate gyrus in both affected individuals and their unaffected first degree relatives when compared with their unaffected second degree relatives. These results suggest that the changes are primarily due to genetic risk and not illness effects, and may represent an intermediate phenotype.

Indexed as

Adaptor Proteins, Signal TransducingAdolescentFemaleFunctional LateralityGyrus CinguliHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeuronsSchizophreniaYoung AdultAdaptor Proteins, Signal TransducingNOS1AP protein, human

Identifiers

PMID20638248
PMCPMC3129334
OpenAlexW1989196304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.