ArticleBrain research2010
Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice.Scientific reports · 2024Article
- Construction and effect evaluation of different sciatic nerve injury models in rats.Translational neuroscience · 2022Article
- The kappa opioid receptor antagonist aticaprant reverses behavioral effects from unpredictable chronic mild stress in male mice.Psychopharmacology · 2020Article
- Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.Scientific reports · 2020Article
- Reward Processing under Chronic Pain from the Perspective of "Liking" and "Wanting": A Narrative Review.Pain research & management · 2019Review
- Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients.Pain reports · 2018Article
- Article
- The cannabinoid system and pain.Neuropharmacology · 2017Review
- Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats.Scientific reports · 2017Article
- Impaired Spinal Glucocorticoid Receptor Signaling Contributes to the Attenuating Effect of Depression on Mechanical Allodynia and Thermal Hyperalgesia in Rats with Neuropathic Pain.Frontiers in cellular neuroscience · 2017Article
- Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats.Frontiers in behavioral neuroscience · 2016Article
- Long-term behavioral effects in a rat model of prolonged postnatal morphine exposure.Behavioral neuroscience · 2015Article
- Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors.Molecular pain · 2015Article
- Pain and depression comorbidity: a preclinical perspective.Behavioural brain research · 2015Review
- Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression.Experimental brain research · 2014Article
- Chronic administration of 5-HT1A receptor agonist relieves depression and depression-induced hypoalgesia.TheScientificWorldJournal · 2014Article
- Brain-network mechanisms underlying the divergent effects of depression on spontaneous versus evoked pain in rats: a multiple single-unit study.Experimental neurology · 2013Article
- Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied.PsyCh journal · 2013Article
- The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain.Neuroscience bulletin · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Clinical observations suggest that depressed patients were less sensitive to experimental pain than healthy subjects. However, few animal studies are reported concerning the association of depression and pain. The purpose of this study was to investigate the effects of unpredictable chronic mild stress (UCMS) induced depression on the perceived intensity of painful stimulation in rats. We measured the thermal and mechanical paw withdrawal thresholds (PWT) of normal and spinal nerve ligated (SNL) rats using hot plate test and von Frey test, respectively. The results showed that rats exposed to UCMS exhibited significantly higher thermal and mechanical pain thresholds in comparison to the non-depressed controls. In particular, the PWT of the SNL group was restored to nearly normal level after three weeks of UCMS, and even comparable to that of the control group. These results strongly suggest that the depressed subjects have decreased sensitivity to externally applied noxious stimulation, which is consistent with our previous findings.
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