ReviewCurrent opinion in biotechnology2010
Molecular-level tradeoffs and metabolic adaptation to simultaneous stressors.
Review in Current opinion in biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Implications of carbon catabolite repression for plant-microbe interactions.Plant communications · 2022Pooled it
- Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy.FEBS letters · 2026Article
- Cell Geometry and Membrane Protein Crowding Constrain Growth Rate, Overflow Metabolism, Respiration, and Maintenance Energy.bioRxiv : the preprint server for biology · 2025Article
- Differential Response of Bacterial Microdiversity to Simulated Global Change.Applied and environmental microbiology · 2022Article
- Microeconomics of Metabolism: The Warburg Effect as Giffen Behaviour.Bulletin of mathematical biology · 2021Article
- Pseudomonas aeruginosa reverse diauxie is a multidimensional, optimized, resource utilization strategy.Scientific reports · 2021Article
- Artificial consortium demonstrates emergent properties of enhanced cellulosic-sugar degradation and biofuel synthesis.NPJ biofilms and microbiomes · 2020Article
- Pseudomonad reverse carbon catabolite repression, interspecies metabolite exchange, and consortial division of labor.Cellular and molecular life sciences : CMLS · 2020Review
- A yield-cost tradeoff governsNPJ systems biology and applications · 2019Article
- Bacterial Tradeoffs in Growth Rate and Extracellular Enzymes.Frontiers in microbiology · 2019Article
- From elementary flux modes to elementary flux vectors: Metabolic pathway analysis with arbitrary linear flux constraints.PLoS computational biology · 2017Review
- Quorum Sensing Communication Modules for Microbial Consortia.ACS synthetic biology · 2016Article
- Engineering microbial consortia for controllable outputs.The ISME journal · 2016Article
- Integrated molecular, physiological and in silico characterization of two Halomonas isolates from industrial brine.Extremophiles : life under extreme conditions · 2016Article
- Aerobically respiring prokaryotic strains exhibit a broader temperature-pH-salinity space for cell division than anaerobically respiring and fermentative strains.Journal of the Royal Society, Interface · 2015Article
- Physiological, biomass elemental composition and proteomic analyses of Escherichia coli ammonium-limited chemostat growth, and comparison with iron- and glucose-limited chemostat growth.Microbiology (Reading, England) · 2015Article
- Physiological and proteomic analysis of Escherichia coli iron-limited chemostat growth.Journal of bacteriology · 2014Article
- Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic.Biofouling · 2013Review
- Synthetic Escherichia coli consortia engineered for syntrophy demonstrate enhanced biomass productivity.Journal of biotechnology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Life is a dynamic process driven by the complex interplay between physical constraints and selection pressures, ranging from nutrient limitation to inhibitory substances to predators. These stressors are not mutually exclusive; microbes have faced concurrent challenges for eons. Genome-enabled systems biology approaches are adapting economic and ecological concepts like tradeoff curves and strategic resource allocation theory to analyze metabolic adaptations to simultaneous stressors. These methodologies can accurately describe and predict metabolic adaptations to concurrent stresses by considering the tradeoff between investment of limiting resources into enzymatic machinery and the resulting cellular function. The approaches represent promising links between computational biology and well-established economic and ecological methodologies for analyzing the interplay between physical constraints and microbial fitness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.