Evidence map›Paper›PMID 20637595›Full record

ReviewCurrent opinion in biotechnology2010

Actin dynamics and endocytosis in yeast and mammals.

Brian J Galletta, Olivia L Mooren, John A Cooper

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
  2. From Cap to Collar: Ontogeny of the Endocytic Collar inJournal of fungi (Basel, Switzerland) · 2025
    Article
  3. Article
  4. CdSe/ZnS Quantum Dots' Impact on In Vitro Actin Dynamics.International journal of molecular sciences · 2024
    Article
  5. Review
  6. Article
  7. Interactions between Quantum Dots and G-Actin.International journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Yeast as a Model to Find New Drugs and Drug Targets forInternational journal of molecular sciences · 2022
    Review
  11. Review
  12. Article
  13. Synaptic tau: A pathological or physiological phenomenon?Acta neuropathologica communications · 2021
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brian J GallettaDepartment of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Olivia L Mooren
John A Cooper

Funding

Molecular Mechanisms in Actin Assembly &Cell MotilityR01GM038542 · NIGMS · WASHINGTON UNIVERSITY · PI COOPER, JOHN A · 1989 to 2013
$7.4M
Coordinate Regulation of the Actin Cytoskeleton and Membranes by DynaminF32GM083538 · NIGMS · WASHINGTON UNIVERSITY · PI MOOREN, OLIVIA L. · 2008 to 2010
$149k
NIGMS NIH HHS F32 GM 083538NIGMS NIH HHS F32 GM083538NIGMS NIH HHS GM 38542NIGMS NIH HHS R01 GM038542
6 · The paper itself

Abstract

Tight regulation of the actin cytoskeleton is critical for many cell functions, including various forms of cellular uptake. Clathrin-mediated endocytosis (CME) is one of the main methods of uptake in many cell types. An intact and properly regulated actin cytoskeleton is required for CME in Saccharomyces cerevisiae. Yeast CME requires the proper regulation of actin polymerization, filament cross-linking, and filament disassembly. Recent studies also point to a role for F-BAR and BAR-domain containing proteins in linking the processes of generating and sensing plasma membrane curvature with those regulating the actin cytoskeleton. Many of these same proteins are conserved in mammalian CME. However, until recently the requirement for actin in mammalian CME was less clear. Several recent studies in mammalian cells provide new support for an actin requirement in the invagination and late stages of CME. This review focuses on the regulation of the actin cytoskeleton during CME in yeast and the emerging evidence for a role for actin during mammalian CME.

Indexed as

ActinsAnimalsClathrin-Coated VesiclesCytoskeletonEndocytosisMammalsActins

Identifiers

PMID20637595
PMCPMC2952672

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.