ArticleCancer letters2010
PTHrP promotes colon cancer cell migration and invasion in an integrin α6β4-dependent manner through activation of Rac1.
Article in Cancer letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- [Overexpression of parathyroid hormone-like hormone facilitates hepatocellular carcinoma progression and correlates with adverse outcomes].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Focal Adhesion Kinase Intersects With the BRD4-MYC Axis and YAP1 to Drive Tumor Cell Growth, Phenotypic Plasticity, Stemness, and Metastatic Potential in Colorectal Cancer.Cancer medicine · 2025Article
- Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells.World journal of gastroenterology · 2021Article
- Underlying Ossification Phenotype in a Murine Model of Metastatic Synovial Sarcoma.International journal of molecular sciences · 2020Article
- Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation.Scientific reports · 2017Article
- Co-expression of parathyroid hormone related protein and TGF-beta in breast cancer predicts poor survival outcome.BMC cancer · 2015Article
- Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development.Developmental biology · 2015Article
- Review
- Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.Molecular cancer therapeutics · 2013Review
- Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma.Oncology reports · 2013Article
- SSX2IP promotes metastasis and chemotherapeutic resistance of hepatocellular carcinoma.Journal of translational medicine · 2013Article
- The multifaceted actions of PTHrP in skeletal metastasis.Future oncology (London, England) · 2012Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Parathyroid hormone-related protein (PTHrP) is expressed by human colon cancer tissue and cell lines. Rac1 GTPase enhances colon cancer cell migration and invasion. Here we report a positive correlation between PTHrP expression and Rac1 activity in LoVo (human colon cancer) cells. The positive effects of PTHrP on Rac1 activity and on cell migration and invasion are mediated via the guanine nucleotide exchange factor Tiam1. Knockdown of integrin α6β4, which is upregulated by PTHrP, negates the PTHrP-mediated increase in Rac1 activation. Integrin α6β4 signals synergistically with growth factor receptors to activate the phosphatidylinositol 3-kinase (PI3-K) pathway. Chemical inhibition of PI3-K negates the PTHrP-mediated effects on Tiam1 and Rac1 activity. Tumors from PTHrP-overexpressing LoVo cells also show increased expression of Tiam1. Taken together, these observations provide evidence of a link between PTHrP and Rac1 activity through integrin α6β4, resulting in enhanced cell migration and invasion. Targeting PTHrP production in colon cancer may thus prove therapeutically beneficial.
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