ArticleStructure (London, England : 1993)2010
Structural dynamics of the magnesium-bound conformation of CorA in a lipid bilayer.
Article in Structure (London, England : 1993), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA.Journal of molecular biology · 2023Article
- Ion selectivity and gating behavior of the CorA-type channel Bpss1228.Frontiers in chemistry · 2022Article
- Article
- Loss of cytosolic MgBiochimica et biophysica acta. General subjects · 2019Article
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- Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.Structure (London, England : 1993) · 2016Article
- Article
- Molecular mechanism of Mg2+-dependent gating in CorA.Nature communications · 2014Article
- Long α helices projecting from the membrane as the dimer interface in the voltage-gated H(+) channel.The Journal of general physiology · 2014Article
- Assessment of the requirements for magnesium transporters in Bacillus subtilis.Journal of bacteriology · 2014Article
- A repulsion mechanism explains magnesium permeation and selectivity in CorA.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Structural insights into the mechanisms of Mg2+ uptake, transport, and gating by CorA.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Symmetry-constrained analysis of pulsed double electron-electron resonance (DEER) spectroscopy reveals the dynamic nature of the KcsA activation gate.Journal of the American Chemical Society · 2012Article
- The periplasmic loop provides stability to the open state of the CorA magnesium channel.The Journal of biological chemistry · 2012Article
- Article
- Mg2+ channel selectivity probed by EPR.Structure (London, England : 1993) · 2010Article
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6 authors.
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Abstract
The transmembrane conformation of Thermotoga maritima CorA, a magnesium transport system, has been studied in its Mg(2+)-bound form by site-directed spin labeling and electron paramagnetic resonance spectroscopy. Probe mobility together with accessibility data were used to evaluate the overall dynamics and relative arrangement of individual transmembrane segments TM1 and TM2. TM1 extends toward the cytoplasmic side creating a water-filled cavity, while TM2 is located in the periphery of the oligomer, contacting the lipid bilayer. A structural model for the conserved extracellular loop was generated based on EPR data and MD simulations, in which residue E316 is located toward the five-fold symmetry axis in position to electrostatically influence divalent ion translocation. Electrostatic analysis of our model suggest that, in agreement with the crystal structure, Mg(2+) -bound CorA is in a closed conformation. The present results suggest that long-range structural rearrangements are necessary to allow Mg(2+) translocation.
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