Evidence map›Paper›PMID 20637410›Full record

ArticleStructure (London, England : 1993)2010

The apo riboswitch as a molecular hydra.

Joseph E Wedekind

Abstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Joseph E WedekindDepartment of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry and Center for RNA Biology, Rochester, NY 14642, USA. joseph.wedekind@rochester.edu

Funding

Mechanisms of Action On Non-Coding RNA MoleculesR01GM063162 · NIGMS · UNIVERSITY OF ROCHESTER · PI WEDEKIND, JOSEPH E · 2001 to 2024
$6.8M
A shared macromolecular X-ray diffraction system in RochesterS10RR026501 · NCRR · UNIVERSITY OF ROCHESTER · PI WEDEKIND, JOSEPH E · 2010 to 2010
$478k
NCRR NIH HHS S10 RR026501NIGMS NIH HHS R01 GM063162
6 · The paper itself

Abstract

Riboswitches "sense" metabolites but knowledge is sparse for structures without bound ligand. Stoddard et al. (2010) determined an apo riboswitch structure "closed" to metabolite binding. Further SAXS, biochemical, and computational analyses support ensemble behavior with interconverting open and closed conformations.

Identifiers

PMID20637410
PMCPMC2913869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.