Evidence map›Paper›PMID 20637279›Full record

ArticleToxicology in vitro : an international journal published in association with BIBRA2010

Chromate-induced sulfur starvation and mRNA mistranslation in yeast are linked in a common mechanism of Cr toxicity.

Sara L Holland, Ekalabya Ghosh, Simon V Avery

Abstract read
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In one paragraph

Article in Toxicology in vitro : an international journal published in association with BIBRA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sara L HollandSchool of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham, UK.
Ekalabya Ghosh
Simon V Avery
University of Nottingham · GB

Funding

Role of Oxidative Mechanisms in the Toxicity of MetalsR01GM057945 · NIGMS · UNIVERSITY OF NOTTINGHAM · PI AVERY, SIMON V · 1999 to 2007
$1.4M
NIGMS NIH HHS R01 GM057945NIGMS NIH HHS R01 GM57945
6 · The paper itself

Abstract

Toxicity of the environmental carcinogen chromate is known to involve sulfur starvation and also error-prone mRNA translation. Here we reconcile those facts using the yeast model. We demonstrate that: (i) cysteine and methionine starvation mimic Cr-induced translation errors, (ii) genetic suppression of S starvation suppresses Cr-induced mistranslation, and (iii) mistranslation requires cysteine and methionine biosynthesis. Therefore, Cr-induced S starvation is the cause of mRNA mistranslation. This establishes a single, novel pathway mediating the toxicity of chromate.

Indexed as

Chromium CompoundsCysteineDNA-Binding ProteinsGene ExpressionIndicators and ReagentsMethionineProtein BiosynthesisReverse Transcriptase Polymerase Chain ReactionRNA, FungalRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSulfurTranscription FactorsChromium Compoundschromium trioxideCysteineDNA-Binding ProteinsIndicators and ReagentsMet32 protein, S cerevisiaeMethionineRNA, FungalRNA, MessengerSaccharomyces cerevisiae ProteinsSulfurTranscription FactorsChromate toxicityframeshiftSaccharomyces cerevisiaeSul1sulfate transport

Identifiers

PMID20637279
PMCPMC2932861
OpenAlexW2039545422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.