ArticleArthritis research & therapy2010
Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers: a case-control study.
Article in Arthritis research & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Perioperative Management of Antirheumatic Medications in Adults with Rheumatoid Arthritis Undergoing Arthroplasty and Other Orthopedic Procedures: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Patient, Surgery, and Hospital Related Risk Factors for Surgical Site Infections following Total Hip Arthroplasty.TheScientificWorldJournal · 2015Pooled it
- [Recommendations of the German Society for Rheumatology on the perioperative approach under therapy with DMARDs and biologicals in inflammatory rheumatic diseases].Zeitschrift fur Rheumatologie · 2014Guideline
- Should anti-TNF therapy be discontinued in rheumatoid arthritis patients undergoing elective orthopaedic surgery? A systematic review of the evidence.Rheumatology international · 2012Pooled it
- Patterns and associated risk of perioperative use of anti-tumor necrosis factor in patients with rheumatoid arthritis undergoing total knee replacement.The Journal of rheumatology · 2013Trial
- Elective primary total hip arthroplasty in rheumatoid arthritis versus osteoarthritis: in-hospital outcomes from the national inpatient sample, 2016-2021.Archives of orthopaedic and trauma surgery · 2026Article
- Prediction of Early Periprosthetic Joint Infection After Total Hip Arthroplasty.Clinical epidemiology · 2022Article
- [Periprosthetic and interprothetic fractures in patients with rheumatism : Characteristics of conservative and surgical treatment].Der Unfallchirurg · 2020Review
- Anti-rheumatic treatment and prosthetic joint infection: an observational study in 494 elective hip and knee arthroplasties.BMC musculoskeletal disorders · 2020Observational
- Immunosuppression and the risk of readmission and mortality in patients with rheumatoid arthritis undergoing hip fracture, abdominopelvic and cardiac surgery.Annals of the rheumatic diseases · 2020Article
- Risk of Biologics and Glucocorticoids in Patients With Rheumatoid Arthritis Undergoing Arthroplasty: A Cohort Study.Annals of internal medicine · 2019Article
- Perioperative management of immunosuppression in patients with rheumatoid arthritis.Current opinion in rheumatology · 2019Review
- Preoperative Evaluation and Management of Patients Receiving Biologic Therapies.The archives of bone and joint surgery · 2019Review
- Prevention of Infection in the Perioperative Setting in Patients with Rheumatic Disease Treated with Immunosuppression.Current rheumatology reports · 2019Review
- Perioperative Management of Patients with Inflammatory Rheumatic Diseases Undergoing Major Orthopaedic Surgery: A Practical Overview.Advances in therapy · 2018Review
- Perioperative Timing of Infliximab and the Risk of Serious Infection After Elective Hip and Knee Arthroplasty.Arthritis care & research · 2017Article
- Moderating effects of immunosuppressive medications and risk factors for post-operative joint infection following total joint arthroplasty in patients with rheumatoid arthritis or osteoarthritis.Seminars in arthritis and rheumatism · 2017Article
- Rheumatoid Arthritis Does Not Increase Risk of Short-term Adverse Events after Total Knee Arthroplasty: A Retrospective Case-control Study.The Journal of rheumatology · 2015Article
- Hydroxyapatite coating does not improve uncemented stem survival after total hip arthroplasty!Acta orthopaedica · 2015Article
- Increased risk of revision for infection in rheumatoid arthritis patients with total hip replacements.Acta orthopaedica · 2015Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe objective of this study was to assess natural microbial agents, history and risk factors for total joint arthroplasty (TJA) infections in patients receiving tumor necrosis factor (TNF)α-blockers, through the French RATIO registry and a case-control study.
methodsCases were TJA infections during TNFα-blocker treatments. Each case was compared to two controls (with TJA and TNFα-blocker therapy, but without TJA infection) matched on age (±15 years), TJA localization, type of rheumatic disorder and disease duration (±15 years). Statistical analyses included univariate and multivariate analyses with conditional logistic regression.
resultsIn the 20 cases (18 rheumatoid arthritis), TJA infection concerned principally the knee (n = 12, 60%) and the hip (n = 5, 25%). Staphylococcus was the more frequent microorganism involved (n = 15, 75%). Four patients (20%) were hospitalized in an intensive care unit and two died from infection. Eight cases (40%) versus 5 controls (13%) had undergone primary TJA or TJA revision for the joint subsequently infected during the last year (P = 0.03). Of these procedures, 5 cases versus 1 control were performed without withdrawing TNFα-blockers (P = 0.08). In multivariate analysis, predictors of infection were primary TJA or TJA revision for the joint subsequently infected within the last year (odds ratio, OR = 88.3; 95%CI 1.1-7,071.6; P = 0.04) and increased daily steroid intake (OR = 5.0 per 5 mg/d increase; 1.1-21.6; P = 0.03). Case-control comparisons showed similar distribution between TNFα-blockers (P = 0.70).
conclusionsIn patients receiving TNFα-blockers, TJA infection is rare but potentially severe. Important risk factors are primary TJA or TJA revision within the last year, particularly when TNFα-blockers are not interrupted before surgery, and the daily steroid intake.
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