Evidence map›Paper›PMID 20635904›Full record

ReviewImmunotherapy2010

Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects.

Myriam N Bouchlaka, Doug Redelman, William J Murphy

Open access · greenAbstract readReview
In one paragraph

Review in Immunotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Reduced-Intensity Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Solid Tumors in Pediatric and Young Adult Patients.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017
    Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. A Prospective Study of Peritransplant Sorafenib for Patients with FLT3-ITD Acute Myeloid Leukemia Undergoing Allogeneic Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Myriam N BouchlakaDepartment of Microbiology & Immunology, University of Nevada, Reno, NV, USA.
Doug Redelman
William J Murphy
University of Nevada, Reno · USUniversity of California, Davis · US

Funding

IT by CD40 stimulation and IL2 against renal cell carcinR01CA095572 · NCI · UNIVERSITY OF NEVADA RENO · PI MURPHY, WILLIAM JOSEPH · 2002 to 2017
$4.0M
Proteasome inhibitor (PS-341) and adoptive immunotherapyR01CA102282 · NCI · UNIVERSITY OF NEVADA RENO · PI MURPHY, WILLIAM JOSEPH · 2004 to 2013
$2.8M
NCI NIH HHS R01 CA095572NCI NIH HHS R01 CA102282
6 · The paper itself

Abstract

Hematopoietic stem cell transplantation (HSCT) is a particularly important treatment for hematologic malignancies. Unfortunately, following allogeneic HSCT, graft-versus-host disease, immunosuppression and susceptibility to opportunistic infections remain among the most substantial problems restricting the efficacy and use of this procedure, particularly for cancer. Adoptive immunotherapy and/or manipulation of the graft offer ways to attack residual cancer as well as other transplant-related complications. Recent exciting discoveries have demonstrated that HSCT could be expanded to solid tissue cancers with profound effects on the effectiveness of adoptive immunotherapy. This review will provide a background regarding HSCT, discuss the complications that make it such a complex treatment procedure following up with current immunotherapeutic strategies and discuss emerging approaches in applying immunotherapy in HSCT for cancer.

Indexed as

AnimalsCombined Modality TherapyDisease Models, AnimalGraft vs Host DiseaseGraft vs Tumor EffectHematopoietic Stem Cell TransplantationHumansImmunotherapy, AdoptiveNeoplasmsTreatment Outcome

Identifiers

PMID20635904
PMCPMC3492055
OpenAlexW2055402835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.