ArticleYonsei medical journal2010
Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus.
Article in Yonsei medical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02340312 (Evaluation of the Duodenal Microbiome in Pediatric Functional Dyspepsia), which is not on this map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Duodenal Microbiome in Pediatric Functional Dyspepsia
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile.Scientific reports · 2021Pooled it
- BDNF and IL-33 Dynamics in an Ultrasound Stress Model of Fibromyalgia-like Phenotypes.International journal of molecular sciences · 2026Article
- The synaptic triad in depression: how stress-related pathways converge on BDNF, NMDA receptor, and MMP-9.Pharmacological reports : PR · 2026Review
- Hippocampal Neurosustainability for Stress Resilience: A Pro-Neurogenic BDNF-Targeted Architectural Enrichment Framework to Overcome Type 2 Allostatic Overload.Brain sciences · 2026Article
- Sex differences in AMPA receptor trafficking proteins.Biology of sex differences · 2026Review
- Neurobiophilia.Brain sciences · 2026Review
- Expression of Neurotrophin Genes in the Hypothalamus of Stressed and Allopregnanolone-Infused Sheep.International journal of molecular sciences · 2025Article
- Brain-derived neurotrophic factor in older adults exposed to simulated indoor overheating.European journal of applied physiology · 2025Article
- Pain Neuroscience Education Reduces Pain and Improves Psychological Variables but Does Not Induce Plastic Changes Measured by Brain-Derived Neurotrophic Factor (BDNF): A Randomized Double-Blind Clinical Trial.Healthcare (Basel, Switzerland) · 2025Article
- Effects of Chaihu Shugan San on Brain Functional Network Connectivity in the Hippocampus of a Perimenopausal Depression Rat Model.Molecular neurobiology · 2024Article
- Chronic Variable Stress and Cafeteria Diet Combination Exacerbate Microglia andInternational journal of molecular sciences · 2024Article
- Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Current neuropharmacology · 2024Review
- Social confrontation stress decreases hepatic fibroblast growth factor-21 expression in aged mice.Biochemistry and biophysics reports · 2023Article
- Administration of growth hormone ameliorates adverse effects of total sleep deprivation.Metabolic brain disease · 2023Article
- Effects of Tail Pinch on BDNF and trkB Expression in the Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats.International journal of molecular sciences · 2023Article
- Altered responsiveness of the antioxidant system in chronically stressed animals: modulation by chronic lurasidone treatment.Psychopharmacology · 2022Article
- Correlation between vitamin D and serum brain derived neurotropic factor levels in type 2 diabetes mellitus patients.Biomedical reports · 2022Article
- Heat-Stress Preconditioning Attenuates Behavioral Responses to Psychological Stress: The Role of HSP-70 in Modulating Stress Responses.International journal of molecular sciences · 2022Article
- Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats.GeroScience · 2022Article
- Islamic praying changes stress-related hormones and genes.Journal of medicine and life · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to explore the dynamic change of brainderived neurotrophic factor (BDNF) mRNA, protein, and tyrosine kinase-coupled receptor (TrkB) mRNA of the rat hippocampus under different stress conditions and to explore the influence of senescence on the productions expression. MATERIALS AND
methodsBy using forced-swimming in 4 degrees C cold ice water and 25 degrees C warm water, young and aged male rats were randomly divided into acute stress (AS) and chronic mild repeated stress (CMRS) subgroups, respectively. BDNF productions and TrkB mRNA in the hippocampus were detected by using Western-blotting and reverse transcription-polymerase chain reaction (RT-PCR), separately, at 15, 30, 60, 180, and 720 min after the last stress session.
resultsThe short AS induced a significant increase in BDNF mRNA and protein in both age groups, but the changes in the young group were substantially greater than those of the aged group (p < 0.005). The CMRS resulted in a decrease in BDNF mRNA and protein, but a significant increase in TrkB mRNA in both young and age groups. The expression of BDNF mRNA and protein in the AS groups were higher than in the CMRS groups at 15, 30, and 60 min after stress.
conclusionThe results indicated that the up/down-regulation of BDNF and TrkB were affected by aging and the stimulus paradigm, which might reflect important mechanisms by which the hippocampus copes with stressful stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.