ArticleJournal of neurology2010
The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism.
Article in Journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Comparative Olfactory Profiles in Parkinson's Disease and Drug-Induced Parkinsonism.Journal of movement disorders · 2024Article
- Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism.NPJ Parkinson's disease · 2022Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?Nature reviews. Neuroscience · 2022Review
- Updated Perspectives on the Management of Drug-Induced Parkinsonism (DIP): Insights from the Clinic.Therapeutics and clinical risk management · 2022Review
- Olfaction in patients with Parkinson's disease: a new threshold test analysis through turning points trajectories.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Recognition and Management of Antipsychotic-Induced Parkinsonism in Older Adults: A Narrative Review.Medicines (Basel, Switzerland) · 2021Review
- Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer's disease dementia.PloS one · 2020Article
- Olfactory Dysfunction as an Early Biomarker in Parkinson's Disease.Neuroscience bulletin · 2017Review
- Clinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism.Journal of movement disorders · 2017Article
- Olfactory loss as a supporting feature in the diagnosis of Parkinson's disease: a pragmatic approach.Journal of neurology · 2013Review
- Olfaction in Parkinson's disease and related disorders.Neurobiology of disease · 2012Review
- Movement disorders induced by antipsychotic drugs: implications of the CATIE schizophrenia trial.Neurologic clinics · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory impairment has been reported in drug-induced parkinsonism (DIP), but the relationship between dopaminergic dysfunction and smell deficits in DIP patients has not been characterized. To this end, we studied 16 DIP patients and 13 patients affected by Parkinson's disease (PD) using the "Sniffin' Sticks" test and [(123)I] FP-CIT SPECT (single-photon emission computed tomography). DIP patients were divided based on normal (n = 9) and abnormal (n = 7) putamen dopamine transporter binding. Nineteen healthy age- and sex-matched subjects served as controls of smell function. Patients with DIP and pathological putamen uptake had abnormal olfactory function. In this group of patients, olfactory TDI scores (odor threshold, discrimination and identification) correlated significantly with putamen uptake values, as observed in PD patients. By contrast, DIP patients with normal putamen uptake showed odor functions-with the exception of the threshold subtest-similar to control subjects. In this group of patients, no significant correlation was observed between olfactory TDI scores and putamen uptake values. The results of our study suggest that the presence of smell deficits in DIP patients might be more associated with dopaminergic loss rather than with a drug-mediated dopamine receptor blockade. These preliminary results might have prognostic and therapeutic implications, as abnormalities in these individuals may be suggestive of an underlying PD-like neurodegenerative process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.