Trial reportPsychopharmacology2010
Alcohol impairment of saccadic and smooth pursuit eye movements: impact of risk factors for alcohol dependence.
Trial report in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Eye Tracking Studies Exploring Cognitive and Affective Processes among Alcohol Drinkers: a Systematic Review and Perspectives.Neuropsychology review · 2021Pooled it
- Acute alcohol rewarding effects as a risk factor for hangover frequency.Addictive behaviors · 2022Trial
- Alcohol-induced performance impairment: a 5-year re-examination study in heavy and light drinkers.Psychopharmacology · 2017Trial
- A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder.Biological psychiatry · 2016Trial
- Acute alcohol response phenotype in heavy social drinkers is robust and reproducible.Alcoholism, clinical and experimental research · 2014Trial
- Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking.Archives of general psychiatry · 2011Trial
- AI-Driven Prediction of Possible Mild Cognitive Impairment Using the Oculo-Cognitive Addition Test (OCAT).Brain sciences · 2026Article
- The eyes have it: Alcohol-induced eye movement impairment and perceived impairment in older adults with and without alcohol use disorder.Alcohol, clinical & experimental research · 2025Article
- Ethanol-Induced Vestibular Dysfunction as a Model for Bilateral Vestibular Syndrome: Similarities in Video Head Impulse Test and Video-Oculography Data.The journal of international advanced otology · 2023Article
- Oculomotor fatigability with decrements of saccade and smooth pursuit for diagnosis of myasthenia gravis.Journal of neurology · 2023Article
- Visual Impairment and Its Associated Factors Among Hypertensive Patients in Amhara Region Referral Hospitals, Ethiopia.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Differential saccade-pursuit coordination under sleep loss and low-dose alcohol.Frontiers in neuroscience · 2022Article
- Anti-saccade as a Tool to Evaluate Neurocognitive Impairment in Alcohol Use Disorder.Frontiers in psychiatry · 2022Review
- Dose-dependent sensorimotor impairment in human ocular tracking after acute low-dose alcohol administration.The Journal of physiology · 2021Article
- Moderate Alcohol Intake Changes Visual Perception by Enhancing V1 Inhibitory Surround Interactions.Frontiers in neuroscience · 2021Article
- Reduced attentional capture by reward following an acute dose of alcohol.Psychopharmacology · 2020Article
- Alcohol effects on response inhibition: Variability across tasks and individuals.Experimental and clinical psychopharmacology · 2018Article
- Neural mechanisms of smooth pursuit eye movements in schizotypy.Human brain mapping · 2015Article
- Comparison of alcohol impairment of behavioral and attentional inhibition.Drug and alcohol dependence · 2012Article
- Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements.Alcoholism, clinical and experimental research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleWhile persons at risk for alcohol dependence by virtue of heavy drinking patterns or family history (FH) of alcohol use disorders have exhibited differential alcohol responses on a variety of measures, few studies have examined alcohol's effects on eye movements in these subgroups.
objectivesThe purpose of this study was to (1) conduct a placebo-controlled, dose-ranging study of alcohol's effects on eye movements and (2) examine the impact of these risk factors on oculomotor response to alcohol.
methodsA within-subject, double-blind laboratory study was conducted in N = 138 heavy (HD; n = 78) and light social drinkers (LD; n = 60) with self-reported positive (FH+) or negative (FH-) family history. Subjects participated in three laboratory sessions in which they consumed a beverage containing a high (0.8 g/kg) or low (0.4 g/kg) dose of alcohol or placebo. Smooth pursuit, pro-saccadic, and anti-saccadic eye movements were recorded before and at two intervals after alcohol consumption.
resultsAlcohol significantly impaired smooth pursuit gain and pro- and anti-saccade latency, velocity, and accuracy in a dose and time specific matter. HD and LD showed similar impairment on smooth pursuit gain and anti-saccade measures, but HD were less impaired in pro-saccade latency, velocity, and accuracy. FH+ and FH- subjects were equally impaired in nearly all pro- and anti-saccade measures, but FH+ were less impaired in smooth pursuit gain.
conclusionsIn sum, alcohol produced systematic impairment on oculomotor functioning, even at a non-intoxicating dose. Furthermore, high- and low-risk drinkers may be vulnerable to select performance deficits relative to eye movement task.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.