ArticlePloS one2010
Drosophila melanogaster as a model host for the Burkholderia cepacia complex.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection.Nature protocols · 2026Review
- UnravelingmSystems · 2025Article
- Remote disruption of intestinal homeostasis by Mycobacterium abscessus is detrimental to Drosophila survival.Scientific reports · 2024Article
- A CRISPR-Cas-associated transposon system for genome editing inApplied and environmental microbiology · 2024Article
- Review
- Methodological tools to study species of the genus Burkholderia.Applied microbiology and biotechnology · 2021Review
- Functional Analysis of Phenazine Biosynthesis Genes inApplied and environmental microbiology · 2021Article
- A multi-host approach to identify a transposon mutant of Pseudomonas aeruginosa LESB58 lacking full virulence.BMC research notes · 2018Article
- Review
- period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection.Current biology : CB · 2016Article
- Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens.Frontiers in microbiology · 2015Review
- Human pathogenic bacteria, fungi, and viruses in Drosophila: disease modeling, lessons, and shortcomings.Virulence · 2014Review
- Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.Virulence · 2013Review
- Identification of quorum sensing-controlled genes in Burkholderia ambifaria.MicrobiologyOpen · 2013Article
- Identification of Burkholderia cenocepacia strain H111 virulence factors using nonmammalian infection hosts.Infection and immunity · 2013Article
- Article
- Diversity of potential pathogenicity and biofilm formation among Burkholderia cepacia complex water, clinical, and agricultural isolates in China.World journal of microbiology & biotechnology · 2012Article
- Article
- The Drosophila melanogaster host model.Journal of oral microbiology · 2012Article
- An integrative approach to ortholog prediction for disease-focused and other functional studies.BMC bioinformatics · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundColonization with bacterial species from the Burkholderia cepacia complex (Bcc) is associated with fast health decline among individuals with cystic fibrosis. In order to investigate the virulence of the Bcc, several alternative infection models have been developed. To this end, the fruit fly is increasingly used as surrogate host, and its validity to enhance our understanding of host-pathogen relationships has been demonstrated with a variety of microorganisms. Moreover, its relevance as a suitable alternative to mammalian hosts has been confirmed with vertebrate organisms. METHODOLOGY/PRINCIPAL
findingsThe aim of this study was to establish Drosophila melanogaster as a surrogate host for species from the Bcc. While the feeding method proved unsuccessful at killing the flies, the pricking technique did generate mortality within the populations. Results obtained with the fruit fly model are comparable with results obtained using mammalian infection models. Furthermore, validity of the Drosophila infection model was confirmed with B. cenocepacia K56-2 mutants known to be less virulent in murine hosts or in other alternative models. Competitive index (CI) analyses were also performed using the fruit fly as host. Results of CI experiments agree with those obtained with mammalian models. CONCLUSIONS/SIGNIFICANCE: We conclude that Drosophila is a useful alternative infection model for Bcc and that fly pricking assays and competition indices are two complementary methods for virulence testing. Moreover, CI results indicate that this method is more sensitive than mortality tests.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.