ArticlePloS one2010
CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- TheBioMed research international · 2018Trial
- Article
- Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents.Frontiers in endocrinology · 2025Review
- Identification of common genetic factors and immune-related pathways associating more than two autoimmune disorders: implications on risk, diagnosis, and treatment.Genomics & informatics · 2024Article
- Inflammatory bowel disease is associated with an increase in the incidence of multiple sclerosis: a retrospective cohort study of 24,934 patients.European journal of medical research · 2024Article
- The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease.Human genetics · 2024Article
- Immune checkpoints: new insights into the pathogenesis of thyroid eye disease.Frontiers in immunology · 2024Review
- IgA Vasculitis: Influence ofJournal of clinical medicine · 2022Article
- CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination.PLoS pathogens · 2021Article
- Association of Multiple Sclerosis Phenotypes with Single Nucleotide Polymorphisms ofBiomolecules · 2020Article
- Association of soluble CD40 levels with -1 C > T CD40 polymorphism and chronic kidney disease in systemic lupus erythematosus.Molecular genetics & genomic medicine · 2019Article
- CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation.Cell reports · 2019Article
- Association between the CD40 rs1883832 polymorphism and Graves' disease risk: a meta-analysis.EXCLI journal · 2019Article
- Association between CD40 rs1883832 and immune-related diseases susceptibility: A meta-analysis.Oncotarget · 2017Article
- Association of CD40 Gene Polymorphisms with Susceptibility to Neuromyelitis Optica Spectrum Disorders.Molecular neurobiology · 2017Article
- CD40 Signaling in Graves Disease Is Mediated Through Canonical and Noncanonical Thyroidal Nuclear Factor κB Activation.Endocrinology · 2017Article
- The Influence of Human Interindividual Variability on the Low-Dose Region of Dose-Response Curve Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Primary B Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Sex differences in comorbidity at diagnosis of multiple sclerosis: A population-based study.Neurology · 2016Article
- Concomitant Thyroid Disorders and Inflammatory Bowel Disease: A Literature Review.BioMed research international · 2016Review
- MS risk allele rs1883832T is associated with decreased mRNA expression of CD40.Journal of molecular neuroscience : MN · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA functional polymorphism located at -1 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation. It has been consistently associated with Graves' disease risk in populations of different ethnicity and genetic proxies of this variant evaluated in genome-wide association studies have shown evidence of an effect in rheumatoid arthritis and multiple sclerosis (MS) susceptibility. However, the protective allele associated with Graves' disease or rheumatoid arthritis has shown a risk role in MS, an effect that we aimed to replicate in the present work. We hypothesized that this functional polymorphism might also show an association with other complex autoimmune condition such as inflammatory bowel disease, given the CD40 overexpression previously observed in Crohn's disease (CD) lesions. METHODOLOGY: Genotyping of rs1883832C>T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry. PRINCIPAL
findingsThe observed effect of the minor allele rs1883832T was replicated in our independent Spanish MS cohort [p = 0.025; OR (95% CI) = 1.12 (1.01-1.23)]. The frequency of the minor allele was also significantly higher in CD patients than in controls [p = 0.002; OR (95% CI) = 1.19 (1.06-1.33)]. This increased predisposition was not detected in UC patients [p = 0.5; OR (95% CI) = 1.04 (0.93-1.17)].
conclusionThe impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions.
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