ArticlePloS one2010
A role for Drosophila dFoxO and dFoxO 5'UTR internal ribosomal entry sites during fasting.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Comprehensive evaluation of caloric restriction-induced changes in the metabolome profile of mice.Nutrition & metabolism · 2022Article
- Starved epithelial cells uptake extracellular matrix for survival.Nature communications · 2017Article
- Article
- O-GlcNAc modification is essential for the regulation of autophagy in Drosophila melanogaster.Cellular and molecular life sciences : CMLS · 2015Article
- Article
- RNA-binding proteins impacting on internal initiation of translation.International journal of molecular sciences · 2013Review
- Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization.Nature communications · 2012Article
- Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.Cancer cell · 2012Article
- Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs.Comparative and functional genomics · 2012Article
- Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling.Molecular systems biology · 2011Article
- Fasting and Caloric Restriction in Cancer Prevention and Treatment.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancerReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
One way animals may cope with nutrient deprivation is to broadly repress translation by inhibiting 5'-cap initiation. However, under these conditions specific proteins remain essential to survival during fasting. Such peptides may be translated through initiation at 5'UTR Internal Ribosome Entry Sites (IRES). Here we show that the Drosophila melanogaster Forkhead box type O (dFoxO) transcription factor is required for adult survival during fasting, and that the 5'UTR of dfoxO has the ability to initiate IRES-mediated translation in cell culture. Previous work has shown that insulin negatively regulates dFoxO through AKT-mediated phosphorylation while dFoxO itself induces transcription of the insulin receptor dInR, which also harbors IRES. Here we report that IRES-mediated translation of both dFoxO and dInR is activated in fasted Drosophila S2 cells at a time when cap-dependent translation is reduced. IRES mediated translation of dFoxO and dInR may be essential to ensure function and sensitivity of the insulin signaling pathway during fasting.
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Registered trials
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