ArticlePloS one2010
Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The MYH9/APOL1 region and chronic kidney disease in European-Americans.Human molecular genetics · 2011Pooled it
- Association of MYH9-rs3752462 polymorphisms with chronic kidney disease among clinically diagnosed hypertensive patients: a case-control study in a Ghanaian population.Clinical hypertension · 2020Article
- Non-diabetic end-stage renal disease in Saudis associated with polymorphism of MYH9 gene but not UMOD gene.Medicine · 2020Observational
- The Relationship Between Haplotype-BasedGenetics · 2019Article
- Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients.International journal of nephrology · 2019Article
- APOL1-Associated Nephropathy: A Key Contributor to Racial Disparities in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Review
- African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era.World journal of nephrology · 2015Review
- APOL1 kidney risk alleles: population genetics and disease associations.Advances in chronic kidney disease · 2014Review
- Genetic variation and adaptation in Africa: implications for human evolution and disease.Cold Spring Harbor perspectives in biology · 2014Review
- Initial steroid sensitivity in children with steroid-resistant nephrotic syndrome predicts post-transplant recurrence.Journal of the American Society of Nephrology : JASN · 2014Article
- Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians.International urology and nephrology · 2013Article
- The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome.BMC nephrology · 2013Article
- Target organ damage in African American hypertension: role of APOL1.Current hypertension reports · 2012Review
- APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis.PloS one · 2012Article
- Article
- Genome-wide association studies of chronic kidney disease: what have we learned?Nature reviews. Nephrology · 2011Review
- APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.Journal of the American Society of Nephrology : JASN · 2011Article
- Multi-ethnic studies in complex traits.Human molecular genetics · 2011Review
- The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus.Nature reviews. Nephrology · 2011Review
- Arrest of the true culprit and acquittal of the innocent? Genetic revelations charge APOL1 variants with kidney disease susceptibility.International urology and nephrology · 2010Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
MYH9 was recently identified as renal susceptibility gene (OR 3-8, p < 10(-8)) for major forms of kidney disease disproportionately affecting individuals of African descent. The risk haplotype (E-1) occurs at much higher frequencies in African Americans (> or = 60%) than in European Americans (< 4%), revealing a genetic basis for a major health disparity. The population distributions of MYH9 risk alleles and the E-1 risk haplotype and the demographic and selective forces acting on the MYH9 region are not well explored. We reconstructed MYH9 haplotypes from 4 tagging single nucleotide polymorphisms (SNPs) spanning introns 12-23 using available data from HapMap Phase II, and by genotyping 938 DNAs from the Human Genome Diversity Panel (HGDP). The E-1 risk haplotype followed a cline, being most frequent within sub-Saharan African populations (range 50-80%), less frequent in populations from the Middle East (9-27%) and Europe (0-9%), and rare or absent in Asia, the Americas, and Oceania. The fixation indexes (F(ST)) for pairwise comparisons between the risk haplotypes for continental populations were calculated for MYH9 haplotypes; F(ST) ranged from 0.27-0.40 for Africa compared to other continental populations, possibly due to selection. Uniquely in Africa, the Yoruba population showed high frequency extended haplotype length around the core risk allele (C) compared to the alternative allele (T) at the same locus (rs4821481, iHs = 2.67), as well as high population differentiation (F(ST(CEU vs. YRI)) = 0.51) in HapMap Phase II data, also observable only in the Yoruba population from HGDP (F(ST) = 0.49), pointing to an instance of recent selection in the genomic region. The population-specific divergence in MYH9 risk allele frequencies among the world's populations may prove important in risk assessment and public health policies to mitigate the burden of kidney disease in vulnerable populations.
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