ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Small particles disrupt postnatal airway development.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Impact of Personal, Subhourly Exposure to Ultrafine Particles on Respiratory Health in Adolescents with Asthma.Annals of the American Thoracic Society · 2022Article
- Emulating Near-Roadway Exposure to Traffic-Related Air Pollution via Real-Time Emissions from a Major Freeway Tunnel System.Environmental science & technology · 2022Article
- Air pollution and lung function in children.The Journal of allergy and clinical immunology · 2021Review
- Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin.Particle and fibre toxicology · 2020Article
- The aryl hydrocarbon receptor as a target of environmental stressors - Implications for pollution mediated stress and inflammatory responses.Redox biology · 2020Review
- Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2020Article
- Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Onset of alveolar recirculation in the developing lungs and its consequence on nanoparticle deposition in the pulmonary acinus.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Early-life exposure to combustion-derived particulate matter causes pulmonary immunosuppression.Mucosal immunology · 2014Article
- Perinatal factors in neonatal and pediatric lung diseases.Expert review of respiratory medicine · 2013Article
- Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs.Particle and fibre toxicology · 2013Article
- Combustion derived ultrafine particles induce cytochrome P-450 expression in specific lung compartments in the developing neonatal and adult rat.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Particulate matter containing environmentally persistent free radicals and adverse infant respiratory health effects: a review.Journal of biochemical and molecular toxicology · 2013Review
- Age-specific effects on rat lung glutathione and antioxidant enzymes after inhaling ultrafine soot.American journal of respiratory cell and molecular biology · 2013Article
- Ambient particulate matter and lung function growth in Chinese children.Epidemiology (Cambridge, Mass.) · 2012Article
- Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Postnatal growth of tracheobronchial airways of Sprague-Dawley rats.Journal of anatomy · 2011Article
- Detecting alterations in pulmonary airway development with airway-by-airway comparison.Annals of biomedical engineering · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Increasing numbers of epidemiologic studies associate air pollution exposure in children with decreased lung function development. The objective of this study was to examine the effects of exposure to combustion-generated fine [230 and 212 nm number mean aerodynamic particle diameter (NMAD)] to ultrafine (73 nm NMAD) particles differing in elemental (EC) and organic (OC) carbon content on postnatal airway development in rats. Neonatal Sprague-Dawley rats were exposed from postnatal day 7 through 25, and lung function and airway architecture were evaluated 81 days of age. In a separate group of rats, cell proliferation was examined after a single particle exposure at 7 days of age. Early life exposure to 73 nm high OC/EC particles altered distal airway architecture and resulted in subtle changes in lung mechanics. Early life exposure to 212 nm high OC/EC particles did not alter lung architecture but did alter lung mechanics in a manner suggestive of central airway changes. In contrast, early life exposure to 230 nm low OC/EC particles did not alter lung architecture or mechanics. A single 6-h exposure to 73 nm high OC/EC particle decreased airway cell proliferation, whereas 212 nm high OC/EC particles increased it and 230 nm low OC/EC particles did not. The early life exposure to ultrafine, high OC/EC particles results in persistent alterations in distal airway architecture that is characterized by an initial decrease in airway cell proliferation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.