Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2010
Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
207 citing papers in PubMed, 2 syntheses or guidelines pooled it, 371 citations in OpenAlex.
- Differences in time to task failure and fatigability between children and young adults: A systematic review and meta-analysis.Frontiers in physiology · 2022Pooled it
- The Effects of Mental Fatigue on Physical Performance: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Acute neuromuscular and metabolic responses to a novel low-load combined isometric and isotonic resistance training protocol.European journal of applied physiology · 2026Trial
- Low carbohydrate availability reduces power output at the moderate-to-heavy transition, impairs efficiency, and increases median power frequency during cycling in females.European journal of applied physiology · 2026Trial
- Activation of skeletal muscle mechanoreceptors and nociceptors reduces the exercise performance of the contralateral homologous muscles.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Trial
- Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial.Journal of the International Society of Sports Nutrition · 2023Trial
- Caffeine alters the breathing pattern during high-intensity whole-body exercise in healthy men.European journal of applied physiology · 2022Trial
- Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease.Experimental physiology · 2022Trial
- Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Trial
- Three weeks of respiratory muscle endurance training improve the OPhysiological reports · 2018Trial
- Effectiveness of inspiratory muscle training on sleep and functional capacity to exercise in obstructive sleep apnea: a randomized controlled trial.Sleep & breathing = Schlaf & Atmung · 2018Trial
- Contribution of blood oxygen and carbon dioxide sensing to the energetic optimization of human walking.Journal of neurophysiology · 2017Trial
- Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Ventilation Increases with Lower Extremity Venous Occlusion in Young Adults.Medicine and science in sports and exercise · 2016Trial
- Alterations in the rate of limb movement using a lower body positive pressure treadmill do not influence respiratory rate or phase III ventilation.BioMed research international · 2015Trial
- Relationship between mean body temperature calculated by two- or three-compartment models and active cutaneous vasodilation in humans: a comparison between cool and warm environments during leg exercise.International journal of biometeorology · 2012Trial
- Implications of group III and IV muscle afferents for high-intensity endurance exercise performance in humans.The Journal of physiology · 2011Trial
- Feedback from group III/IV afferents in skeletal muscle slows heart rate acceleration when transitioning from rest to low-intensity exercise in males.Experimental physiology · 2026Article
- Exercise hyperpnoea: Unravelling layers of regulation.The Journal of physiology · 2026Article
147 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the role of somatosensory feedback on cardioventilatory responses to rhythmic exercise in five men. In a double-blind, placebo-controlled design, subjects performed the same leg cycling exercise (50/100/150/325 ± 19 W, 3 min each) under placebo conditions (interspinous saline, L(3)-L(4)) and with lumbar intrathecal fentanyl impairing central projection of spinal opioid receptor-sensitive muscle afferents. Quadriceps strength was similar before and after fentanyl administration. To evaluate whether a cephalad migration of fentanyl affected cardioventilatory control centers in the brain stem, we compared resting ventilatory responses to hypercapnia (HCVR) and cardioventilatory responses to arm vs. leg cycling exercise after each injection. Similar HCVR and minor effects of fentanyl on cardioventilatory responses to arm exercise excluded direct medullary effects of fentanyl. Central command during leg exercise was estimated via quadriceps electromyogram. No differences between conditions were found in resting heart rate (HR), ventilation [minute ventilation (VE)], or mean arterial pressure (MAP). Quadriceps electromyogram, O(2) consumption (VO(2)), and plasma lactate were similar in both conditions at the four steady-state workloads. Compared with placebo, a substantial hypoventilation during fentanyl exercise was indicated by the 8-17% reduction in VE/CO(2) production (VCO(2)) secondary to a reduced breathing frequency, leading to average increases of 4-7 Torr in end-tidal PCO(2) (P < 0.001) and a reduced hemoglobin saturation (-3 ± 1%; P < 0.05) at the heaviest workload (∼90% maximal VO(2)) with fentanyl. HR was reduced 2-8%, MAP 8-13%, and ratings of perceived exertion by 13% during fentanyl vs. placebo exercise (P < 0.05). These findings demonstrate the essential contribution of muscle afferent feedback to the ventilatory, cardiovascular, and perceptual responses to rhythmic exercise in humans, even in the presence of unaltered contributions from other major inputs to cardioventilatory control.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.