ArticleHuman molecular genetics2010
Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders.
Article in Human molecular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Genetic Variants from Large Cohorts and Familial Studies Implicate Common Mechanisms in Schizophrenia.Biology · 2026Review
- Partial rescue of schizophrenia-related phenotypes in young adult Sp4 hypomorphic mice.Journal of psychiatric research · 2025Article
- Efficacy of the combination of water aerobics and metacognitive training on psychological and physical health variables and their relationship with SP1 and SP4 biomarkers in people with psychosis: a study protocol.Frontiers in psychology · 2024Article
- Schizophrenia Genomics: Convergence on Synaptic Development, Adult Synaptic Plasticity, or Both?Biological psychiatry · 2022Review
- Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice.PloS one · 2018Article
- Mechanisms regulating dendritic arbor patterning.Cellular and molecular life sciences : CMLS · 2017Review
- Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies.British journal of pharmacology · 2017Review
- Preclinical Models to Investigate Mechanisms of Negative Symptoms in Schizophrenia.Schizophrenia bulletin · 2017Review
- Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons.Biochimica et biophysica acta · 2016Article
- Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity.Genes, brain, and behavior · 2016Review
- GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Characterization of spatio-temporal epidural event-related potentials for mouse models of psychiatric disorders.Scientific reports · 2015Article
- Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Article
- Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice.The international journal of neuropsychopharmacology · 2015Article
- Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning.Developmental neurobiology · 2015Article
- Article
- The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase.Frontiers in cellular neuroscience · 2015Article
- Store-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons.Science signaling · 2014Article
- Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling.Journal of neurochemistry · 2014Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The reduced expression of the Sp4 gene in Sp4 hypomorphic mice resulted in subtle vacuolization in the hippocampus as well as deficits in sensorimotor gating and contextual memory, putative endophenotypes for schizophrenia and other psychiatric disorders. In this study, we examined both spatial learning/memory and hippocampal long-term potentiation (LTP) of Sp4 hypomorphic mice. Impaired spatial learning/memory and markedly reduced LTP were found. To corroborate the functional studies, the expression of N-methyl-D-aspartate (NMDA) glutamate receptors was investigated with both western blot and immunohistochemical analyses. The reduced expression of the Sp4 gene decreased the level of the NR1 subunit of NMDA receptors in Sp4 hypomorphic mice. In human, SP4 gene was found to be deleted sporadically in schizophrenia patients, corroborating evidence that polymorphisms of human SP4 gene are associated with schizophrenia and other psychiatric disorders. Impaired NMDA neurotransmission has been implicated in several human psychiatric disorders. As yet, it remains unclear how mutations of candidate susceptibility genes for these disorders may contribute to the disruption of NMDA neurotransmission. Sp4 hypomorphic mice could therefore serve as a genetic model to investigate impaired NMDA functions resulting from loss-of-function mutations of human SP4 gene in schizophrenia and/or other psychiatric disorders. Furthermore, aberrant expression of additional genes, besides NMDAR1, likely also contributes to the behavioral abnormalities in Sp4 hypomorphic mice. Thus, further investigation of the Sp4 pathway may provide novel insights in our understanding of a variety of neuropsychiatric disorders.
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