ArticleNutrition & metabolism2010
Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice.
Article in Nutrition & metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Suboptimal Selenium Intake Produces Sex-Specific Alterations in Metabolic Profiles in Western Diet-Fed Obese Mice.International journal of molecular sciences · 2026Article
- Effect of Muscle Contraction Under Caloric Restriction on Irisin and FGF21 Secretion in Mice.Physiological research · 2025Article
- Muscle Type-Specific Modulation of Autophagy Signaling in Obesity: Effects of Caloric Restriction and Exercise.Journal of obesity & metabolic syndrome · 2025Article
- Gradual increase in energy intake over 8 weeks with voluntary wheel running limits body weight change in male rats.The British journal of nutrition · 2025Article
- Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids.Advances in nutrition (Bethesda, Md.) · 2021Review
- The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight.Journal of diabetes and metabolic disorders · 2019Article
- Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats.Journal of diabetes investigation · 2019Article
- Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Treadmill running suppresses the vulnerability of dopamine D2 receptor deficiency to obesity and metabolic complications: a pilot study.Journal of exercise nutrition & biochemistry · 2018Article
- Intermittent Fasting with or without Exercise Prevents Weight Gain and Improves Lipids in Diet-Induced Obese Mice.Nutrients · 2018Article
- Hepatic iron storage is related to body adiposity and hepatic inflammation.Nutrition & metabolism · 2017Article
- Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet.International journal of endocrinology · 2017Article
- Adiponectin mediates the additive effects of combining daily exercise with caloric restriction for treatment of non-alcoholic fatty liver.International journal of obesity (2005) · 2016Article
- Effect of feeding a high-fat diet independently of caloric intake on reproductive function in diet-induced obese female rats.Archives of medical science : AMS · 2016Article
- Branched-Chain Amino Acid Supplementation in Combination with Voluntary Running Improves Body Composition in Female C57BL/6 Mice.Journal of dietary supplements · 2016Article
- Caloric Restriction and Formalin-Induced Inflammation: An Experimental Study in Rat Model.Iranian Red Crescent medical journal · 2015Article
- The role for adipose tissue in weight regain after weight loss.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Review
- Voluntary exercise and green tea enhance the expression of genes related to energy utilization and attenuate metabolic syndrome in high fat fed mice.Molecular nutrition & food research · 2014Article
- Article
- In case of obesity, longevity-related mechanisms lead to anti-inflammation.Age (Dordrecht, Netherlands) · 2014Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.
methodsAdult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression.
resultsEndurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.
conclusionsCR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.