ArticleHelicobacter2010
Role of mucin Lewis status in resistance to Helicobacter pylori infection in pediatric patients.
Article in Helicobacter, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Role of Sialic Acid in Brachyspira hyodysenteriae Adhesion to Pig Colonic Mucins.Infection and immunity · 2019Article
- Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins.Mucosal immunology · 2019Article
- Article
- Article
- Helicobacter suis binding to carbohydrates on human and porcine gastric mucins and glycolipids occurs via two modes.Virulence · 2018Article
- Influence of the viscosity of healthy and diseased human mucins on the motility of Helicobacter pylori.Scientific reports · 2018Article
- Mucus-Pathogen Interactions in the Gastrointestinal Tract of Farmed Animals.Microorganisms · 2018Review
- BabA-mediated adherence of pediatric ulcerogenic H. pylori strains to gastric mucins at neutral and acidic pH.Virulence · 2018Article
- Aeromonas salmonicida Growth in Response to Atlantic Salmon Mucins Differs between Epithelial Sites, Is Governed by Sialylated andInfection and immunity · 2017Article
- Review
- Structural Diversity of Human Gastric Mucin Glycans.Molecular & cellular proteomics : MCP · 2017Article
- BabA dependent binding of Helicobacter pylori to human gastric mucins cause aggregation that inhibits proliferation and is regulated via ArsS.Scientific reports · 2017Article
- Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions.The European respiratory journal · 2016Review
- New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression.World journal of gastroenterology · 2015Article
- Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers.World journal of gastroenterology · 2014Article
- Mucins in Gastric Cancer - An Update.Journal of gastrointestinal & digestive system · 2013Article
- Helicobacter pylori infection impairs the mucin production rate and turnover in the murine gastric mucosa.Infection and immunity · 2013Article
- Article
- Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers.Digestive diseases and sciences · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundHelicobacter pylori causes gastritis, peptic ulcer and is a risk factor for adenocarcinoma and lymphoma of the stomach. Gastric mucins, carrying highly diverse carbohydrate structures, present functional binding sites for H. pylori and may play a role in pathogenesis. However, little information is available regarding gastric mucin in children with and without stomach diseases. MATERIALS AND
methodsExpression of mucins and glycosylation was studied by immunohistochemistry on gastric biopsies from 51 children with and without H. pylori infection and/or peptic ulcer disease.
resultsIn all children, MUC5AC was present in the surface epithelium and MUC6 in the glands. No MUC6 in the surface epithelium or MUC2 was detected in any section. The Le(b) and Le(a) blood group antigens were present in the surface epithelium of 80% and 29% of children, respectively. H. pylori load was higher in Le(b) negative children than in Le(b) positive individuals (mean +/- SEM 17.8 +/- 3.5 vs 10.8 +/- 1.5; p < 0.05), but there was no correlation between Le(a) or Le(b) status and gastritis, nodularity, and gastric or duodenal ulcer (DU). Expression of sialyl-Le(x) was associated with H. pylori infection, and DU.
conclusionsMucin expression and glycosylation is similar in children and adults. However, in contrast to adults, pediatric H. pylori infection is not accompanied by aberrant expression of MUC6 or MUC2. Furthermore, the lower H. pylori density in Le(b) positive children indicates that H. pylori is suppressed in the presence of gastric mucins decorated with Le(b), the binding site of the H. pylori BabA adhesin.
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Registered trials
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