ArticleGenes, brain, and behavior2010
Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?
Article in Genes, brain, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis.Psychiatric genetics · 2014Pooled it
- Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function.Scientific reports · 2016Trial
- Enhancing link prediction in biomedical knowledge graphs with BioPathNet.Nature biomedical engineering · 2026Article
- Maternal Epigenetic Dysregulation as a Possible Risk Factor for Neurodevelopmental Disorders.Genes · 2023Article
- The Influence of HLA Alleles on the Affective Distress Profile.International journal of environmental research and public health · 2022Article
- Imbalance in Sirt1 Alternative Splicing in Response to Chronic Stress during the Adolescence Period in Female Mice.International journal of molecular sciences · 2022Article
- 7,8-Dihydroxyflavone, a Tropomyosin-Kinase Related Receptor B Agonist, Produces Fast-Onset Antidepressant-Like Effects in Rats Exposed to Chronic Mild Stress.Psychiatry investigation · 2016Article
- Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.Biological psychology · 2015Article
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- Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-α treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Neurobiology of anxious depression: a review.Depression and anxiety · 2013Review
- Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childhood.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Excessive daytime sleepiness in sleep disorders.Journal of thoracic disease · 2012Article
- Bringing a developmental perspective to anxiety genetics.Development and psychopathology · 2012Review
- Fluoxetine pharmacogenetics in child and adult populations.European child & adolescent psychiatry · 2012Review
- A latent modeling approach to genotype-phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotype.Archives of women's mental health · 2012Article
- A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Influence of candidate genes on attention problems in children: a longitudinal study.Behavior genetics · 2011Article
- Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.PloS one · 2011Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
There are two major hypotheses regarding the etiology of anxiety and depression: the mono-amine hypothesis and the hypothesis of an abnormal stress response acting partly via reduced neurogenesis. Association studies have focused on genes involved in these processes, but with inconclusive results. This study investigated the effect of 45 single nucleotide polymorphisms (SNPs) in genes encoding for serotonin receptors 1A, 1D, 2A, catechol-O-methyltransferase (COMT), tryptophane hydroxylase type 2 (TPH2), brain derived neurotrophic factor (BDNF), PlexinA2 and regulators of G-protein-coupled signaling (RGS) 2, 4, 16. Anxious depression (A/D) symptoms were assessed five times in 11 years in over 11 000 adults with 1504 subjects genotyped and at age 7, 10, 12 and during adolescence in over 20 000 twins with 1078 subjects genotyped. In both cohorts, a longitudinal model with one latent factor loading on all A/D measures over time was analysed. The genetic association effect modeled at the level of this latent factor was 60% and 70% heritable in the children and adults, respectively, and explained around 50% of the total phenotypic variance. Power analyses showed that the samples contained 80% power to detect an effect explaining between 1.4% and 3.6% of the variance. However, no SNP showed a consistent effect on A/D. To conclude, this longitudinal study in children and adults found no association of SNPs in the serotonergic system or core regulators of neurogenesis with A/D. Overall, there has been no convincing evidence, so far, for a role of genetic variation in these pathways in the development of anxiety and depression.
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