ArticleExperimental and clinical cardiology2010
Homocysteine and markers of inflammation in acute coronary syndrome.
Article in Experimental and clinical cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05297097 (The Impact of a Human Breast Milk Supplement on Epigenetic and Cellular Markers), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of a Human Breast Milk Supplement on Epigenetic and Cellular Markers
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
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- Vascular transcriptional and metabolic changes precede progressive intrarenal microvascular rarefaction in autosomal dominant polycystic kidney disease.American journal of physiology. Renal physiology · 2026Article
- Recent Choline Intake Is Inversely Associated with Inflammation in Pregnancy - Evidence from the Canadian APrON Cohort.The Journal of nutrition · 2026Article
- Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health.Journal of neurochemistry · 2025Review
- Using Machine Learning to Detect Factors That Affect Homocysteine in Healthy Elderly Taiwanese Men.Biomedicines · 2025Article
- The Interplay of Dietary Choline and Methyl Donors in Modulating Maternal Inflammation: Insights from Project Viva.The Journal of nutrition · 2025Article
- Systematic Review and Meta-Analysis to Explore the Relationship of Increased Homocysteine, Lipid Levels and Lipid Ratios In-Cad.Journal of pharmacy & bioallied sciences · 2025Review
- Predictive factors for multivessel disease in patients with acute coronary syndrome: analysis from the CCC-ACS project in China.BMC cardiovascular disorders · 2024Article
- High methionine diet mediated oxidative stress and proteasome impairment causes toxicity in liver.Scientific reports · 2024Article
- Association between homocysteine and coronary artery disease-trend over time and across the regions: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Article
- Potential inflammatory targets in the integrative health care of patients with sickle cell disease.Experimental and therapeutic medicine · 2023Article
- High-Dose Vitamin B6 (Pyridoxine) Displays Strong Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated Monocytes.Biomedicines · 2023Article
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- Consumption of Cashew (Nutrients · 2022Article
- Association Between Endophthalmitis and the Incidence of Acute Coronary Syndrome in Patients With Ankylosing Spondylitis: A Nationwide, Population-Based Cohort Study.Frontiers in immunology · 2022Article
- The predictive values of GGT and Hcy in the risk stratifications and prognoses of NSTE-ACS patients.American journal of translational research · 2021Article
- Redox Imbalance and Methylation Disturbances in Early Childhood Obesity.Oxidative medicine and cellular longevity · 2021Article
- Article
- Clinical utility of mean platelet volume and immature platelet fraction in acute coronary syndrome.Biomedical journal · 2019Article
- Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury.American journal of physiology. Cell physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn elevated level of homocysteine (Hcy) has been shown to be a cardiovascular risk factor in the majority of research studies. Recently, it was found to be associated with new risk factors such as inflammatory markers.
objectivesTo investigate the distribution of plasma total Hcy (tHcy) and the levels of inflammatory markers in patients with acute coronary syndrome (ACS), and to evaluate the association between these parameters and the severity of the disease.
methodsA total of 122 patients with ACS and 80 control subjects were recruited from the cardiac intensive care unit of the Military Hospital of Tunis, Tunisia. Lipid profile and the levels of tHcy, high-sensitivity C-reactive protein (HsCRP), interleukin (IL)-6, IL-8, IL-1beta and tumour necrosis factor-alpha (TNFalpha) were determined for all participants. The distribution of these parameters were compared between groups and according to the number of diseased vessels in patients with ACS.
resultsACS patients had significantly elevated levels of tHcy (P<0.01), HsCRP (P<0.001), IL-6 (P<0.001), TNFalpha (P<0.001), folates (P<0.05) and vitamin B(12) (P<0.001), but lower high-density lipoprotein cholesterol (P<0.05) levels. The analysis of the association between these parameters and the number of diseased vessels showed significant differences in tHcy, HsCRP, IL-6 and TNFalpha, with positive correlations. Significantly negative correlations were found between the number of diseased vessels and folate (r=-0.34; P<0.01), and vitamin B(12) (r=-0.22; P<0.01).
conclusionElevated levels of tHcy, IL-6, TNFalpha and HsCRP appear to be associated with a greater number of diseased arteries and, consequently, the severity of coronary artery disease.
Indexed as
Identifiers
20631860PMC2898531W219653125What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.