ArticleFrontiers in neuroanatomy2010
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Article in Frontiers in neuroanatomy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Recapitulation of plaque formation, tau pathology, and neurodegeneration in a human 3D matrix model of Alzheimer's disease.Cell reports methods · 2026Article
- Parvalbumin interneurons in the hippocampal formation of individuals with Alzheimer's disease: a neuropathological study of abnormal phosphorylated tau in neurons.Frontiers in neuroanatomy · 2025Article
- CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer's disease.Translational psychiatry · 2024Article
- Voltage-Gated NaLife (Basel, Switzerland) · 2023Review
- Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer's disease.Translational neurodegeneration · 2022Article
- Membrane interaction to intercellular spread of pathology in Alzheimer's disease.Frontiers in neuroscience · 2022Review
- Dendritic spines are lost in clusters in Alzheimer's disease.Scientific reports · 2021Article
- Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer's disease.Brain : a journal of neurology · 2021Article
- Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer's Disease.Frontiers in neuroanatomy · 2019Article
- 3D morphology-based clustering and simulation of human pyramidal cell dendritic spines.PLoS computational biology · 2018Article
- A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients.Journal of Alzheimer's disease : JAD · 2018Article
- Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene.Psychoneuroendocrinology · 2017Article
- Three-dimensional spatial modeling of spines along dendritic networks in human cortical pyramidal neurons.PloS one · 2017Article
- Morphometric alterations of Golgi apparatus in Alzheimer's disease are related to tau hyperphosphorylation.Neurobiology of disease · 2017Article
- Selective alterations of neurons and circuits related to early memory loss in Alzheimer's disease.Frontiers in neuroanatomy · 2014Article
- Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- The influence of phospho-τ on dendritic spines of cortical pyramidal neurons in patients with Alzheimer's disease.Brain : a journal of neurology · 2013Article
- Characterization of axo-axonic synapses in the piriform cortex of Mus musculus.The Journal of comparative neurology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurofibrillary tangles (NFT) represent one of the main neuropathological features in the cerebral cortex associated with Alzheimer's disease (AD). This neurofibrillary lesion involves the accumulation of abnormally hyperphosphorylated or abnormally phosphorylated microtubule-associated protein tau into paired helical filaments (PHF-tau) within neurons. We have used immunocytochemical techniques and confocal microscopy reconstructions to examine the distribution of PHF-tau-immunoreactive (ir) cells, and their perisomatic GABAergic and glutamatergic innervations in the hippocampal formation and adjacent cortex of AD patients. Furthermore, correlative light and electron microscopy was employed to examine these neurons and the perisomatic synapses. We observed two patterns of staining in PHF-tau-ir neurons, pattern I (without NFT) and pattern II (with NFT), the distribution of which varies according to the cortical layer and area. Furthermore, the distribution of both GABAergic and glutamatergic terminals around the soma and proximal processes of PHF-tau-ir neurons does not seem to be altered as it is indistinguishable from both control cases and from adjacent neurons that did not contain PHF-tau. At the electron microscope level, a normal looking neuropil with typical symmetric and asymmetric synapses was observed around PHF-tau-ir neurons. These observations suggest that the synaptic connectivity around the perisomatic region of these PHF-tau-ir neurons was apparently unaltered.
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