ReviewNature reviews. Cancer2010
The shunt problem: control of functional shunting in normal and tumour vasculature.
Review in Nature reviews. Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The diagnostic performance of ultrafast MRI to differentiate benign from malignant breast lesions: a systematic review and meta-analysis.European radiology · 2024Pooled it
- Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Pooled it
- Vessel size and perfusion-derived vascular habitat refines prediction of treatment failure to bevacizumab in recurrent glioblastomas: validation in a prospective cohort.European radiology · 2023Trial
- Transport properties of pancreatic cancer describe gemcitabine delivery and response.The Journal of clinical investigation · 2014Trial
- Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.Nature medicine · 2013Trial
- Hypoxia-targeted BOLD MRI signal heterogeneity as a complementary metric for glioblastoma characterization: a pilot study.Journal of neuro-oncology · 2026Article
- Self-assembly of tumor-related vascularized colorectal tumoroid-on-a-chip for precision medicine drug testing.Cell reports. Medicine · 2026Article
- Bridging tumor biology and radiomics through an ultra-large physics-driven vascular model.npj biomedical innovations · 2026Article
- Quantitative spectral parameters of photon-counting detector CT for noninvasive prediction of PD-L1 expression in non-small cell lung cancer.BMC medical imaging · 2026Article
- Shunt: pathophysiological mechanisms and clinical implications of ineffective circulating volume.Frontiers in physiology · 2026Review
- Circumferential actomyosin bundles anchored by CCM1 drive endothelial cell contraction and vessel constriction.Nature communications · 2025Article
- Early-phase semi-quantitative analysis versus full time-course quantitative modeling of ultrafast dynamic contrast-enhanced MRI for breast cancer diagnosis, molecular subtyping, and treatment response prediction.Insights into imaging · 2025Article
- A theoretical model for oxygen transport to the cerebral cortex: effects of flow redistribution by penetrating arterioles.Microvascular research · 2025Article
- Ultrafast Breast MRI: A Narrative Review.Journal of personalized medicine · 2025Review
- Isolated human adipose microvessels retain native microvessel structure and recapitulate sprouting angiogenesis.Angiogenesis · 2025Article
- Simulation of Conducted Responses in Microvascular Networks: Role of Gap Junction Current Rectification.Microcirculation (New York, N.Y. : 1994) · 2025Article
- Unveiling the potential of biomechanics in pioneering innovative strategies for cancer therapy.Theranostics · 2025Review
- The role of coronary microcirculation in heart failure with preserved ejection fraction: An unceasing odyssey.Heart failure reviews · 2025Review
- Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues.Angiogenesis · 2024Article
- The Value of Contrast-Enhanced Ultrasound (CEUS) in the Evaluation of Central Lung Cancer with Obstructive Atelectasis.Diagnostics (Basel, Switzerland) · 2024Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short pathways become enlarged and flow bypasses long pathways). Such adaptation requires information about tissue metabolic status to be communicated upstream to feeding vessels, through conducted responses. We propose that impaired vascular communication in tumour microvascular networks, leading to functional shunting, is a primary cause of dysfunctional microcirculation and local hypoxia in cancer. We suggest that anti-angiogenic treatment of tumours may restore vascular communication and thereby improve or normalize flow distribution in tumour vasculature.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.