Evidence map›Paper›PMID 20631750›Full record

ArticleThe Journal of investigative dermatology2010

Grabbing amphiregulin by the tail to better understand keratinocyte growth.

John T Seykora

Abstract readComment
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury.American journal of respiratory cell and molecular biology · 2012
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

John T SeykoraDepartment of Dermatology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19101, USA. john.seykora@uphs.upenn.edu
University of Pennsylvania · US

Funding

Understanding molecular mechanisms underlying the formation of the blue nevus andP30AR057217 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI STANLEY, JOHN R · 2009 to 2013
$3.2M
The role of srcasm in keratinocyte biologyR01AR051380 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SEYKORA, JOHN T. · 2005 to 2009
$1.6M
NIAMS NIH HHS P30-AR057217NIAMS NIH HHS R01 AR051380
6 · The paper itself

Abstract

Amphiregulin (AREG) is an important regulator of cellular growth in keratinocytes, carcinomas, and hyperproliferative epidermal disorders, including psoriasis. Stoll and colleagues present data suggesting that the cytoplasmic carboxy-terminal domain of amphiregulin plays an important role in regulating autocrine keratinocyte growth through the epidermal growth factor receptor. These observations raise novel and interesting biological questions regarding the function of the cytoplasmic C-terminal region of AREG.

Indexed as

AmphiregulinEGF Family of ProteinsGlycoproteinsHumansIntercellular Signaling Peptides and ProteinsKeratinocytesProtein Structure, TertiarySignal TransductionAmphiregulinAREG protein, humanEGF Family of ProteinsGlycoproteinsIntercellular Signaling Peptides and Proteins

Identifiers

PMID20631750
OpenAlexW1992428696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.