ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Neurogenetics and pharmacology of learning, motivation, and cognition.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed.
- Activation of D1 receptors affects human reactivity and flexibility to valued cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Effects of tolcapone and bromocriptine on cognitive stability and flexibility.Psychopharmacology · 2018Trial
- DRD2 and DRD4 genes related to cognitive deficits in HIV-infected adults who abuse alcohol.Behavioral and brain functions : BBF · 2015Trial
- Dopamine, locus of control, and the exploration-exploitation tradeoff.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Role of dopamine D2 receptors in human reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Love to win or hate to Lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment.Journal of cognitive neuroscience · 2014Trial
- How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis.The European journal of neuroscience · 2012Trial
- COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition.Biological psychiatry · 2012Trial
- Human cognitive flexibility depends on dopamine D2 receptor signaling.Psychopharmacology · 2011Trial
- Discovery and optimization of a novel non-nitrocatechol COMT inhibitor for modulating levodopa metabolism.Journal of pharmaceutical analysis · 2026Article
- The Reward Positivity Tracks Positive Reward Prediction Errors From Feedback to Cues During Reinforcement Learning.Psychophysiology · 2026Article
- From symptom-based heterogeneity to mechanism-based profiling in youth ADHD: the promise of computational psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
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- Cranial radiation disrupts dopaminergic signaling and connectivity in the mammalian brain.Acta neuropathologica communications · 2025Article
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- Pioneering pain management with botulinum toxin type A: From anti-inflammation to regenerative therapies.Heliyon · 2025Review
- Adaptive chunking improves effective working memory capacity in a prefrontal cortex and basal ganglia circuit.bioRxiv : the preprint server for biology · 2024Article
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- Predicted utility modulates working memory fidelity in the brain.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Many of the individual differences in cognition, motivation, and learning-and the disruption of these processes in neurological conditions-are influenced by genetic factors. We provide an integrative synthesis across human and animal studies, focusing on a recent spate of evidence implicating a role for genes controlling dopaminergic function in frontostriatal circuitry, including COMT, DARPP-32, DAT1, DRD2, and DRD4. These genetic effects are interpreted within theoretical frameworks developed in the context of the broader cognitive and computational neuroscience literature, constrained by data from pharmacological, neuroimaging, electrophysiological, and patient studies. In this framework, genes modulate the efficacy of particular neural computations, and effects of genetic variation are revealed by assays designed to be maximally sensitive to these computations. We discuss the merits and caveats of this approach and outline a number of novel candidate genes of interest for future study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.