ReviewCurrent opinion in organ transplantation2010
Complement in organ transplantation.
Review in Current opinion in organ transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03791476 (A Phase I/II,Single Center,Randomized,Double-Blind,Placebo-Controlled Study to Evaluate the Feasibility of Using Human Recombinant C1 Inhibitor), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase I/II,Single Center,Randomized,Double-Blind,Placebo-Controlled Study to Evaluate the Feasibility of Using Human Recombinant C1 Inhibitor(RUCONEST®) as a Therapeutic Strategy to Reduce the Incidence of Delayed Graft Function in Recipients of Kidneys From Donation After Cardio-Circulatory Death
Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- The local complement activation on vascular bed of patients with systemic sclerosis: a hypothesis-generating study.PloS one · 2015Trial
- Plasma complement levels are associated with primary graft dysfunction and mortality after lung transplantation.American journal of respiratory and critical care medicine · 2014Trial
- The time-dependent changes in serum immunoglobulin after kidney transplantation and its association with infection.Frontiers in immunology · 2024Article
- Innate immune modulation in transplantation: mechanisms, challenges, and opportunities.Frontiers in transplantation · 2023Review
- Mouse Sertoli Cells Inhibit Humoral-Based Immunity.International journal of molecular sciences · 2022Article
- Tipping the balance: intricate roles of the complement system in disease and therapy.Seminars in immunopathology · 2021Review
- Multiplex gene analysis reveals T-cell and antibody-mediated rejection-specific upregulation of complement in renal transplants.Scientific reports · 2021Article
- Aberrant activation of the complement system in renal grafts is mediated by cold storage.American journal of physiology. Renal physiology · 2021Article
- Complement Components in the Diagnosis and Treatment after Kidney Transplantation-Is There a Missing Link?Biomolecules · 2021Review
- Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Predictive biomarkers for graft rejection in pig-to-non-human primate corneal xenotransplantation.Xenotransplantation · 2019Article
- A Single Nucleotide C3 Polymorphism Associates With Clinical Outcome After Lung Transplantation.Frontiers in immunology · 2019Article
- The Expanding Field of Secondary Antibody Deficiency: Causes, Diagnosis, and Management.Frontiers in immunology · 2019Review
- Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes?Journal of immunology research · 2017Article
- Association Between Cytokines and Their Receptor Antagonist Gene Polymorphisms and Clinical Risk Factors and Acute Rejection Following Renal Transplantation.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins.Molecular immunology · 2015Article
- Clinical immune-monitoring strategies for predicting infection risk in solid organ transplantation.Clinical & translational immunology · 2014Review
- Complement in Action: An Analysis of Patent Trends from 1976 Through 2011.Advances in experimental medicine and biology · 2013Article
- Progress and Trends in Complement Therapeutics.Advances in experimental medicine and biology · 2013Article
- A novel role of complement in retinal degeneration.Investigative ophthalmology & visual science · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThe aim of this review is to bring to attention the most recent advances made in understanding the role of complement components in both innate and adaptive immune responses in solid organ transplantation with emphasis on the kidney. RECENT
findingsAlongside recent findings related to the role of anaphylatoxins in modulating adaptive immune responses, there has been a genomic study to assess the expression of inflammatory markers in kidney transplantation, showing significant involvement of some complement molecules in predicting graft function. Modulators of complement pathway activity such as decay accelerating factor (CD55) and CD59 have also been shown to have a role in graft rejection. Potential new therapeutic targets related to complement proteins are being investigated. SUMMARY: The mechanism of rejection in solid organ transplantation is influenced by the initial inflammatory response and subsequent adaptive allo-immune response, both of which have been shown to be affected by various complement components. Due to limitations of existing treatments, new approaches are needed to better control these responses to improve graft survival. Built on an expanding knowledge of complement involvement, targeted blocking of the effector complement molecules and modulating the expression of complement inhibitors has suggested potentially useful approaches for reducing the effect of inflammatory damage from cold ischaemia as well as reducing the activation of the adaptive immune system related to complement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.