ArticleJPEN. Journal of parenteral and enteral nutrition
Effect of free fatty acids on bilirubin-albumin binding affinity and unbound bilirubin in premature infants.
Article in JPEN. Journal of parenteral and enteral nutrition. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Parenteral Lipid Dose and Bilirubin Neurotoxicity in Extremely Preterm Infants: A Factorial Randomized Trial.The Journal of pediatrics · 2026Trial
- Effects of soybean lipid infusion on triglyceride and unbound free fatty acid levels in preterm infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019Trial
- Unbound bilirubin and risk of severe neurodevelopmental impairment in extremely low birthweight newborns.Pediatric research · 2025Article
- Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice.Cell death discovery · 2024Article
- Article
- Effect of Reduced Versus Usual Lipid Emulsion Dosing on Bilirubin Neurotoxicity and Neurodevelopmental Impairment in Extremely Preterm Infants: Study Protocol for a Randomized Controlled Trial.Research square · 2023Article
- The effect of different intravenous lipids on free bilirubin levels in premature infants.European journal of clinical nutrition · 2022Article
- Bilirubin binding in jaundiced newborns: from bench to bedside?Pediatric research · 2018Review
- Bilirubin Albumin Binding and Unbound Unconjugated Hyperbilirubinemia in Premature Infants.The Journal of pediatrics · 2018Observational
- Effects of Soybean Lipid Infusion on Unbound Free Fatty Acids and Unbound Bilirubin in Preterm Infants.The Journal of pediatrics · 2017Article
- Bilirubin Binding Capacity in the Preterm Neonate.Clinics in perinatology · 2016Review
- Newborn jaundice technologies: unbound bilirubin and bilirubin binding capacity in neonates.Seminars in perinatology · 2011Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundThe author has previously shown that intravenous lipid intake may be associated with an increase in unbound bilirubin in infants < or =28 weeks gestational age. The objective of this study was to evaluate whether this increase in unbound bilirubin is mediated by free fatty acids and to examine the secondary effect of free fatty acids on bilirubin-albumin binding affinity.
methodsA prospective study was conducted to include 26 infants < or =32 weeks gestational age with indirect hyperbilirubinemia and receiving intravenous lipids during the first 10 postnatal days. Blood samples were collected for unbound bilirubin, binding affinity, and free fatty acid measurement at varying intravenous lipid intakes (1-3 g/kg/d). Regression analyses were performed to evaluate the roles of free fatty acids and binding affinity as mediators.
resultsIntravenous lipid intake was significantly associated with an increase in free fatty acids and unbound bilirubin in infants < or =28 weeks but not >28 weeks gestational age. In infants < or =28 weeks gestational age, each unit increase in free fatty acids was significantly associated with a decrease in binding affinity, which was significantly associated with an increase in unbound bilirubin.
conclusionsIn infants < or =28 weeks gestational age, intravenous lipid intake may be associated with an increase in unbound bilirubin, and this is mediated by an increase in free fatty acids and a secondary decrease in binding affinity. In infants >28 weeks gestational age, higher intravenous lipid intake may be used because it is unassociated with increases in free fatty acids and unbound bilirubin.
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