ArticleClinical and vaccine immunology : CVI2010
Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies.
Article in Clinical and vaccine immunology : CVI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 94 citations in OpenAlex.
- Scabies Diagnosis: A Narrative Review of Diagnostic Methods, Clinical Misdiagnosis, and Emerging Directions.Journal of clinical medicine · 2026Review
- Clinical features of 170 Chinese scabies cases and the therapeutic efficacy of sulfur ointment.PLoS neglected tropical diseases · 2026Article
- Parasitic Infections as Reversible Hyper-IgE Phenocopies in Children with Markedly Elevated IgE: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- An Unexpected Dupilumab Reaction.Cureus · 2026Article
- Tiny Troublemakers-A Comprehensive Approach to Crusted Scabies.Diagnostics (Basel, Switzerland) · 2025Article
- Genomics reveal local skin immune response key to control sarcoptic mange in Iberian ibex (Capra pyrenaica).BMC genomics · 2024Article
- Scabies vaccines: where we stand and challenges ahead.Parasitology research · 2024Review
- Scabies in infants and children - a narrative review.European journal of pediatrics · 2024Review
- Scabies: Immunopathogenesis and pathological changes.Parasitology research · 2024Review
- Assessment of scabies and its associated factors in Hawassa Zuria District, Southern Ethiopia: A cross-sectional study.PloS one · 2024Article
- Commentary: Transcriptome analysis of host inflammatory responses to the ectoparasitic miteFrontiers in immunology · 2023Article
- Crusted Scabies, a Neglected Tropical Disease: Case Series and Literature Review.Infectious disease reports · 2022Review
- Are humanized IgE reporter systems potential game changers in serological diagnosis of human parasitic infection?Parasitology research · 2022Article
- Scabies Infestation and Risk of Acute Myocardial Infarction: A Population-Based Cohort Study.Journal of personalized medicine · 2022Article
- Laboratory-based diagnosis of scabies: a review of the current status.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Review
- Immunomodulatory effects of two recombinant arginine kinases inFrontiers in immunology · 2022Article
- Review
- Pruritus as a Distinctive Feature of Type 2 Inflammation.Vaccines · 2021Review
- Molecular detection and characterization ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Transcriptome Analysis of Host Inflammatory Responses to the Ectoparasitic MiteFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scabies, a parasitic skin infestation by the burrowing "itch" mite Sarcoptes scabiei, causes significant health problems for children and adults worldwide. Crusted scabies is a particularly severe form of scabies in which mites multiply into the millions, causing extensive skin crusting. The symptoms and signs of scabies suggest host immunity to the scabies mite, but the specific resistant response in humans remains largely uncharacterized. We used 4 scabies mite recombinant proteins with sequence homology to extensively studied house dust mite allergens to investigate a differential immune response between ordinary scabies and the debilitating crusted form of the disease. Subjects with either disease form showed serum IgE against recombinant S. scabiei cysteine and serine proteases and apolipoprotein, whereas naive subjects showed minimal IgE reactivity. Significantly (P < 0.05) greater serum IgE and IgG4 binding to mite apolipoprotein occurred in subjects with crusted scabies than in those with ordinary scabies. Both subject groups showed strong proliferative responses (peripheral blood mononuclear cells) to the scabies antigens, but the crusted scabies group showed increased secretion of the Th2 cytokines interleukin 5 (IL-5) and IL-13 and decreased Th1 cytokine gamma interferon (IFN-gamma) in response to the active cysteine protease. These data confirm that a nonprotective allergic response occurs in the crusted disease form and demonstrate that clinical severity is associated with differences in the type and magnitude of the antibody and cellular responses to scabies proteins. A quantitative IgE inhibition assay identified IgE immunoreactivity of scabies mite antigens distinct from that of house dust mite antigens, which is potentially important for specific scabies diagnosis and therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.