ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
Folic acid in early pregnancy: a public health success story.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 114 citations in OpenAlex.
- Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025Review
- Fundamental origins of neural tube defects with a basis in genetics and nutrition.Experimental brain research · 2025Review
- Periconceptional maternal folate supplementation impacts a diverse range of congenital malformations.Pediatric research · 2024Article
- Global neurosurgery: Reflections on myelomeningocele in the Zanzibar archipelago (Tanzania).World neurosurgery: X · 2023Article
- The roles of JAK2/STAT3 signaling in fusion of the secondary palate.Disease models & mechanisms · 2023Article
- A quest for genetic causes underlying signaling pathways associated with neural tube defects.Frontiers in pediatrics · 2023Review
- Article
- Periconceptional Mediterranean diet during pregnancy on children's health.Journal of preventive medicine and hygiene · 2022Review
- Methionine synthase supports tumour tetrahydrofolate pools.Nature metabolism · 2021Article
- The timing and quality of antenatal care received by women attending a primary care centre in Iquitos, Peru: A facility exit survey.PloS one · 2020Article
- Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid.Disease models & mechanisms · 2019Article
- MicroRNA-655-3p and microRNA-497-5p inhibit cell proliferation in cultured human lip cells through the regulation of genes related to human cleft lip.BMC medical genomics · 2019Article
- Omega-3 polyunsaturated fatty acid intake norms and preterm birth rate: a cross-sectional analysis of 184 countries.BMJ open · 2019Article
- Prevalent genotypes of methylenetetrahydrofolate reductase (MTHFR) in recurrent miscarriage and recurrent implantation failure.Journal of assisted reproduction and genetics · 2018Article
- The Role of Hedgehog Signalling in the Formation of the Ventricular Septum.Journal of developmental biology · 2017Review
- Effects of Folic Acid and Homocysteine on the Morphogenesis of Mouse Cephalic Neural Crest Cells In Vitro.Cellular and molecular neurobiology · 2017Article
- High levels of iron supplementation prevents neural tube defects in the Fpn1Birth defects research · 2017Article
- Prevention of neural tube defects in Lrp2 mutant mouse embryos by folic acid supplementation.Birth defects research · 2017Article
- Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate.American journal of medical genetics. Part A · 2016Article
- Safe use of high intakes of folic acid: research challenges and paths forward.Nutrition reviews · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Folate is a water-soluble B vitamin that must be obtained in the diet or through supplementation. For >50 yr, it has been known that folate plays an integral role in embryonic development. In mice, inactivation of genes in the folate pathway results in malformations of the neural tube, heart, and craniofacial structures. It has been shown that diets and blood levels of women who had a fetus with a neural tube defect are low for several micronutrients, particularly folate. Periconceptional use of folic acid containing supplements decreased recurrent neural tube defects in the offspring of women with a previously affected child and the occurrence of a neural tube defect and possibly other birth defects in the offspring of women with no prior history. Based on these findings, the U.S. Public Health Service recommended that all women at risk take folic acid supplements, but many did not. Mandatory food fortification programs were introduced in numerous countries, including the United States, to improve folate nutritional status and have resulted in a major decrease in neural tube defect prevalence. The success story of folate represents the cooperation of embryologists, experimentalists, epidemiologists, public health scientists, and policymakers.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.