ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Efferent pathways modulate hyperactivity in inferior colliculus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Ginkgo biloba for tinnitus.The Cochrane database of systematic reviews · 2022Pooled it
- Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- Cognitive behavioural therapy for tinnitus.The Cochrane database of systematic reviews · 2020Pooled it
- Sound therapy (using amplification devices and/or sound generators) for tinnitus.The Cochrane database of systematic reviews · 2018Pooled it
- Zinc supplementation for tinnitus.The Cochrane database of systematic reviews · 2016Pooled it
- Amplification with hearing aids for patients with tinnitus and co-existing hearing loss.The Cochrane database of systematic reviews · 2014Pooled it
- Auditory Network Discoherence in Chronic Tinnitus.medRxiv : the preprint server for health sciences · 2026Article
- Circuit architecture and axonal branching in the efferent auditory system.Hearing research · 2026Review
- An Insight into Role of Auditory Brainstem in Tinnitus: A Systematic Review of Diagnostic Assessments.Audiology research · 2025Review
- Cross-Modal Tinnitus Remediation: A Tentative Theoretical Framework.Brain sciences · 2024Article
- Betahistine for tinnitus.The Cochrane database of systematic reviews · 2018Review
- Objective assessment of subjective tinnitus through contralateral suppression of otoacoustic emissions by white noise: effects of frequency, gender, tinnitus bilaterality and age.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2018Article
- The effects of repetitive transcranial magnetic stimulation in an animal model of tinnitus.Scientific reports · 2016Article
- Salicylate-Induced Hearing Loss Trigger Structural Synaptic Modifications in the Ventral Cochlear Nucleus of Rats via Medial Olivocochlear (MOC) Feedback Circuit.Neurochemical research · 2016Article
- Tinnitus: Maladaptive auditory-somatosensory plasticity.Hearing research · 2016Review
- Neuromodulation (desynchronisation) for tinnitus in adults.The Cochrane database of systematic reviews · 2015Article
- Animal models of spontaneous activity in the healthy and impaired auditory system.Frontiers in neural circuits · 2015Review
- Single unit hyperactivity and bursting in the auditory thalamus of awake rats directly correlates with behavioural evidence of tinnitus.The Journal of physiology · 2014Article
- Effects of furosemide on cochlear neural activity, central hyperactivity and behavioural tinnitus after cochlear trauma in guinea pig.PloS one · 2014Article
- Underlying mechanisms of tinnitus: review and clinical implications.Journal of the American Academy of Audiology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Animal models have demonstrated that mild hearing loss caused by acoustic trauma results in spontaneous hyperactivity in the central auditory pathways. This hyperactivity has been hypothesized to be involved in the generation of tinnitus, a phantom auditory sensation. We have recently shown that such hyperactivity, recorded in the inferior colliculus, is still dependent on cochlear neural output for some time after recovery (up to 6 weeks). We have now studied the capacity of an intrinsic efferent system, i.e., the olivocochlear system, to alter hyperactivity. This system is known to modulate cochlear neural output. Anesthetized guinea pigs were exposed to a loud sound and after 2 or 3 weeks of recovery, single-neuron recordings in inferior colliculus were made to confirm hyperactivity. Olivocochlear axons were electrically stimulated and effects on cochlear neural output and on highly spontaneous neurons in inferior colliculus were assessed. Olivocochlear stimulation suppressed spontaneous hyperactivity in the inferior colliculus. This result is in agreement with our earlier finding that hyperactivity can be modulated by altering cochlear neural output. Interestingly, the central suppression was generally much larger and longer lasting than reported previously for primary afferents. Blockade of the intracochlear effects of olivocochlear system activation eliminated some but not all of the effects observed on spontaneous activity, suggesting also a central component to the effects of stimulation. More research is needed to investigate whether these central effects of olivocochlear efferent stimulation are due to central intrinsic circuitry or to coactivation of central efferent collaterals to the cochlear nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.