ArticleJournal of virology2010
Identification of key residues in virulent canine distemper virus hemagglutinin that control CD150/SLAM-binding activity.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Article
- A novel pseudotype derived of the canine distemper virus for adapter-mediated lentiviral transductionMolecular therapy. Methods & clinical development · 2025Article
- Molecular epidemiology and emerging genotypes of canine distemper virus in Istanbul, Türkiye.BMC veterinary research · 2025Article
- Global Phylogenetic Analysis of the CDV Hemagglutinin Gene Reveals Positive Selection on Key Receptor-Binding Sites.Viruses · 2025Article
- Canine Distemper Virus: Origins, Mutations, Diagnosis, and Epidemiology in Mexico.Life (Basel, Switzerland) · 2024Review
- Article
- Article
- FeMV is a cathepsin-dependent unique morbillivirus infecting the kidneys of domestic cats.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neuropathologic and molecular aspects of a canine distemper epizootic in red foxes in Germany.Scientific reports · 2022Article
- First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil.Scientific reports · 2021Article
- Clustered Lysine Residues of the Canine Distemper Virus Matrix Protein Regulate Membrane Association and Budding Activity.Journal of virology · 2020Article
- Review
- Mink SLAM V-Region V74I Substitutions Contribute to the Formation of Syncytia Induced by Canine Distemper Virus.Frontiers in veterinary science · 2020Article
- Article
- Modulation of Host Immunity by the Human Metapneumovirus.Clinical microbiology reviews · 2016Review
- Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM.Journal of virology · 2016Article
- Phylodynamic analysis of the canine distemper virus hemagglutinin gene.BMC veterinary research · 2015Article
- SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes.Journal of virology · 2015Article
- Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process.PLoS pathogens · 2015Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morbillivirus cell entry is controlled by hemagglutinin (H), an envelope-anchored viral glycoprotein determining interaction with multiple host cell surface receptors. Subsequent to virus-receptor attachment, H is thought to transduce a signal triggering the viral fusion glycoprotein, which in turn drives virus-cell fusion activity. Cell entry through the universal morbillivirus receptor CD150/SLAM was reported to depend on two nearby microdomains located within the hemagglutinin. Here, we provide evidence that three key residues in the virulent canine distemper virus A75/17 H protein (Y525, D526, and R529), clustering at the rim of a large recessed groove created by beta-propeller blades 4 and 5, control SLAM-binding activity without drastically modulating protein surface expression or SLAM-independent F triggering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.