ArticleJournal of virology2010
The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 38 citations in OpenAlex.
- Molecular mechanism of Tembusu virus nonstructural protein 5 antagonising RNA interference.Veterinary research · 2026Article
- Defining Distinct RNA-Protein Interactomes of SARS-CoV-2 Genomic and Subgenomic RNAs.Journal of proteome research · 2024Article
- Mammalian viral suppressors of RNA interference.Trends in biochemical sciences · 2022Review
- The NS4A Protein of Classical Swine Fever Virus Suppresses RNA Silencing in Mammalian Cells.Journal of virology · 2022Article
- Mammalian antiviral systems directed by small RNA.PLoS pathogens · 2021Review
- MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak.Journal of translational medicine · 2021Review
- Artificial miRNA mediated resistance in tobacco against Jatropha leaf curl Gujarat virus by targeting RNA silencing suppressors.Scientific reports · 2021Article
- Non-Coding RNAs and SARS-Related Coronaviruses.Viruses · 2020Review
- Article
- SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells.Science China. Life sciences · 2020Article
- Hepatitis C Virus NS2 Protein Suppresses RNA Interference in Cells.Virologica Sinica · 2020Article
- The Capsid Protein of Semliki Forest Virus Antagonizes RNA Interference in Mammalian Cells.Journal of virology · 2020Article
- RNAi suppressor: The hidden weapon of SARS-CoV.Journal of biosciences · 2020Review
- Prospects for RNAi Therapy of COVID-19.Frontiers in bioengineering and biotechnology · 2020Review
- Article
- Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats.Viruses · 2019Article
- Slicing and dicing viruses: antiviral RNA interference in mammals.The EMBO journal · 2019Review
- s8ORF2 protein of infectious salmon anaemia virus is a RNA-silencing suppressor and interacts with Salmon salar Mov10 (SsMov10) of the host RNAi machinery.Virus genes · 2018Article
- An RNAi-based high-throughput screening assay to identify small molecule inhibitors of hepatitis B virus replication.The Journal of biological chemistry · 2017Article
- Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA silencing suppressors (RSSs) are well studied for plant viruses but are not well defined to date for animal viruses. Here, we have identified an RSS from a medically important positive-sense mammalian virus, Severe acute respiratory syndrome coronavirus. The viral 7a accessory protein suppressed both transgene and virus-induced gene silencing by reducing the levels of small interfering RNA (siRNA). The suppression of silencing was analyzed by two independent assays, and the middle region (amino acids [aa] 32 to 89) of 7a was responsible for suppression. Finally, the RNA suppression property and the enhancement of heterologous replicon activity by the 7a protein were confirmed for animal cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.