ArticleDevelopment (Cambridge, England)2010
Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Drosophila embryo cellularization is tuned by the viscoelastic properties of membrane-cortex linkers.Biophysical journal · 2026Article
- Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration.Nature communications · 2025Article
- Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development.Results and problems in cell differentiation · 2024Review
- Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization.Seminars in cell & developmental biology · 2023Review
- Key roles of Arf small G proteins and biosynthetic trafficking for animal development.Small GTPases · 2019Review
- Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium.PLoS genetics · 2019Article
- The exocyst complex and Rab5 are required for abscission by localizing ESCRT III subunits to the cytokinetic bridge.Journal of cell science · 2019Article
- Decreased proteinase A excretion by strengthening its vacuolar sorting and weakening its constitutive secretion in Saccharomyces cerevisiae.Journal of industrial microbiology & biotechnology · 2017Article
- Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir.Developmental cell · 2016Article
- Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogaster.Development (Cambridge, England) · 2016Article
- The Exocyst Complex in Health and Disease.Frontiers in cell and developmental biology · 2016Review
- Exocyst-Dependent Membrane Addition Is Required for Anaphase Cell Elongation and Cytokinesis in Drosophila.PLoS genetics · 2015Article
- A rapid, membrane-dependent pathway directs furrow formation through RalA in the early Drosophila embryo.Development (Cambridge, England) · 2015Article
- RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization.PLoS genetics · 2015Article
- The plasma membrane flattens out to fuel cell-surface growth during Drosophila cellularization.Developmental cell · 2013Article
- Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.Cell host & microbe · 2013Article
- Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst.The EMBO journal · 2013Article
- Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.Current opinion in cell biology · 2012Review
- Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.Nature immunology · 2012Article
- Deconstructing host-pathogen interactions in Drosophila.Disease models & mechanisms · 2012Review
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Cellularization of the Drosophila embryo is the process by which a syncytium of approximately 6000 nuclei is subdivided into discrete cells. In order to individualize the cells, massive membrane addition needs to occur by a process that is not fully understood. The exocyst complex is required for some, but not all, forms of exocytosis and plays a role in directing vesicles to appropriate domains of the plasma membrane. Sec5 is a central component of this complex and we here report the isolation of a new allele of sec5 that has a temperature-sensitive phenotype. Using this allele, we investigated whether the exocyst complex is required for cellularization. Embryos from germline clones of the sec5(ts1) allele progress normally through cycle 13. At cellularization, however, cleavage furrows do not invaginate between nuclei and consequently cells do not form. A zygotically translated membrane protein, Neurotactin, is not inserted into the plasma membrane and instead accumulates in cytoplasmic puncta. During cellularization, Sec5 becomes concentrated at the apical end of the lateral membranes, which is likely to be the major site of membrane addition. Subsequently, Sec5 concentrates at the sub-apical complex, indicating a role for Sec5 in the polarized epithelium. Thus, the exocyst is necessary for, and is likely to direct, the polarized addition of new membrane during this form of cytokinesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.