ArticleBiomaterials2010
The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Enhanced Nanobubble Formation: Gold Nanoparticle Conjugation to Qβ Virus-like Particles.ACS nano · 2023Article
- Article
- Modeling of Solid-Tumor Microenvironment in Zebrafish (Danio Rerio) Larvae.Advances in experimental medicine and biology · 2020Review
- Article
- Actein Inhibits the Proliferation and Adhesion of Human Breast Cancer Cells and Suppresses MigrationFrontiers in pharmacology · 2018Article
- Review
- High drug-loading nanomedicines: progress, current status, and prospects.International journal of nanomedicine · 2017Review
- Review
- Article
- Intraoperative diagnostics and elimination of residual microtumours with plasmonic nanobubbles.Nature nanotechnology · 2016Article
- The Combination of Laser Therapy and Metal Nanoparticles in Cancer Treatment Originated From Epithelial Tissues: A Literature Review.Journal of lasers in medical sciences · 2016Review
- All-in-one processing of heterogeneous human cell grafts for gene and cell therapy.Molecular therapy. Methods & clinical development · 2016Article
- Gold Nanotheranostics: Proof-of-Concept or Clinical Tool?Nanomaterials (Basel, Switzerland) · 2015Review
- Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale.Small (Weinheim an der Bergstrasse, Germany) · 2015Review
- A fresh look at zebrafish from the perspective of cancer research.Journal of experimental & clinical cancer research : CR · 2015Review
- Efficient synthesis of a maghemite/gold hybrid nanoparticle system as a magnetic carrier for the transport of platinum-based metallotherapeutics.International journal of molecular sciences · 2015Article
- Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model.American journal of cancer research · 2015Article
- On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles.Nature medicine · 2014Article
- From seeing to believing: labelling strategies for in vivo cell-tracking experiments.Interface focus · 2013Article
- Multifunctional gold nanoparticles for diagnosis and therapy of disease.Molecular pharmaceutics · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Cell theranostics is a new approach that unites diagnosis, therapy and confirmation (guidance) of the results of therapy in one single process at cell level, thus principally improving both the rapidity and precision of treatment. The ideal theranostic agent will support all three of the above functions in vivo with cellular resolution, allowing individual assessment of disease state and the elimination of diseased cells while leaving healthy cells intact. We have developed and evaluated plasmonic nanobubbles (PNBs) as an in vivo tunable theranostic cellular agent in zebrafish hosting prostate cancer xenografts. PNBs were selectively generated around gold nanoparticles in cancer cells in the zebrafish with short single laser pulses. By varying the energy of the laser pulse, we dynamically tuned the PNB size in a theranostic sequence of two PNBs: an initial small PNB detected a cancer cell through optical scattering, followed by a second bigger PNB, which mechanically ablated this cell without damage to surrounding tissue, while its optical scattering confirmed the destruction of the cell. Thus PNBs supported the diagnosis and guided ablation of individual human cancer cells in a living organism without damage to the host.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.